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• W2127264744 abstract "Mechanisms for the uptake and transport of carotenoids, essential nutrients for humans, are not well understood in any animal system. The Y ( Yellow blood ) gene, a critical cocoon color determinant in the silkworm Bombyx mori , controls the uptake of carotenoids into the intestinal mucosa and the silk gland. Here we provide evidence that the Y gene corresponds to the intracellular carotenoid-binding protein ( CBP ) gene. In the Y recessive strain, the absence of an exon, likely due to an incorrect mRNA splicing caused by a transposon-associated genomic deletion, generates a nonfunctional CBP mRNA, resulting in colorless hemolymph and white cocoons. Enhancement of carotenoid uptake and coloration of the white cocoon was achieved by germ-line transformation with the CBP gene. This study demonstrates the existence of a genetically facilitated intracellular process beyond passive diffusion for carotenoid uptake in the animal phyla, and paves the way for modulating silk color and lipid content through genetic engineering." @default.
• W2127264744 created "2016-06-24" @default.
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• W2127264744 date "2007-05-22" @default.
• W2127264744 modified "2023-10-12" @default.
• W2127264744 title "Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of the <i>Yellow blood</i> gene" @default.
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• W2127264744 doi "https://doi.org/10.1073/pnas.0702860104" @default.
• W2127264744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1885607" @default.
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