FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127271876> ?p ?o ?g. }

• W2127271876 endingPage "80" @default.
• W2127271876 startingPage "63" @default.
• W2127271876 abstract "Trypanosomatid parasitic protozoans of the genus Leishmania are autotrophic for both folate and unconjugated pteridines. Leishmania salvage these metabolites from their mammalian hosts and insect vectors through multiple transporters. Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both folates and unconjugated pteridines. PTR1 can act as a metabolic bypass of DHFR inhibition, reducing the effectiveness of existing antifolate drugs. Leishmania possess a reduced set of folate-dependent metabolic reactions and can salvage many of the key products of folate metabolism from their hosts. For example, they lack purine synthesis, which normally requires 10-formyltetrahydrofolate, and instead rely on a network of purine salvage enzymes. Leishmania elaborate at least three pathways for the synthesis of the key metabolite 5,10-methylene-tetrahydrofolate, required for the synthesis of thymidylate, and for 10-formyltetrahydrofolate, whose presumptive function is for methionyl-tRNAMet formylation required for mitochondrial protein synthesis. Genetic studies have shown that the synthesis of methionine using 5-methyltetrahydrofolate is dispensable, as is the activity of the glycine cleavage complex, probably due to redundancy with serine hydroxymethyltransferase. Although not always essential, the loss of several folate metabolic enzymes results in attenuation or loss of virulence in animal models, and a null DHFR-TS mutant has been used to induce protective immunity. The folate metabolic pathway provides numerous opportunities for targeted chemotherapy, with strong potential for ‘repurposing' of compounds developed originally for treatment of human cancers or other infectious agents." @default.
• W2127271876 created "2016-06-24" @default.
• W2127271876 creator A5007063454 @default.
• W2127271876 creator A5064083499 @default.
• W2127271876 date "2011-10-24" @default.
• W2127271876 modified "2023-10-03" @default.
• W2127271876 title "Folate metabolic pathways in <i>Leishmania</i>" @default.
• W2127271876 cites W1510112285 @default.
• W2127271876 cites W1843371601 @default.
• W2127271876 cites W1976868461 @default.
• W2127271876 cites W1981753496 @default.
• W2127271876 cites W1983111672 @default.
• W2127271876 cites W1985734471 @default.
• W2127271876 cites W1986799526 @default.
• W2127271876 cites W1989550386 @default.
• W2127271876 cites W1990271015 @default.
• W2127271876 cites W1992089740 @default.
• W2127271876 cites W1994842701 @default.
• W2127271876 cites W1995892898 @default.
• W2127271876 cites W2002253224 @default.
• W2127271876 cites W2009376745 @default.
• W2127271876 cites W2011280216 @default.
• W2127271876 cites W2011889809 @default.
• W2127271876 cites W2012372447 @default.
• W2127271876 cites W2020327537 @default.
• W2127271876 cites W2024585751 @default.
• W2127271876 cites W2031688897 @default.
• W2127271876 cites W2042652437 @default.
• W2127271876 cites W2045780278 @default.
• W2127271876 cites W2053908153 @default.
• W2127271876 cites W2056861778 @default.
• W2127271876 cites W2060098125 @default.
• W2127271876 cites W2075832971 @default.
• W2127271876 cites W2083224849 @default.
• W2127271876 cites W2088884818 @default.
• W2127271876 cites W2090359600 @default.
• W2127271876 cites W2092522917 @default.
• W2127271876 cites W2100404110 @default.
• W2127271876 cites W2107579072 @default.
• W2127271876 cites W2109364945 @default.
• W2127271876 cites W2110201133 @default.
• W2127271876 cites W2112454145 @default.
• W2127271876 cites W2115928361 @default.
• W2127271876 cites W2124017621 @default.
• W2127271876 cites W2124796751 @default.
• W2127271876 cites W2135877083 @default.
• W2127271876 cites W2137052579 @default.
• W2127271876 cites W2139406994 @default.
• W2127271876 cites W2142352599 @default.
• W2127271876 cites W2145912883 @default.
• W2127271876 cites W2148259795 @default.
• W2127271876 cites W2148686101 @default.
• W2127271876 cites W2150201082 @default.
• W2127271876 cites W2155479980 @default.
• W2127271876 cites W2155754160 @default.
• W2127271876 cites W2161709854 @default.
• W2127271876 cites W2176123637 @default.
• W2127271876 cites W232916448 @default.
• W2127271876 cites W2914760410 @default.
• W2127271876 cites W3975443 @default.
• W2127271876 cites W4291984557 @default.
• W2127271876 doi "https://doi.org/10.1042/bse0510063" @default.
• W2127271876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3278214" @default.
• W2127271876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22023442" @default.
• W2127271876 hasPublicationYear "2011" @default.
• W2127271876 type Work @default.
• W2127271876 sameAs 2127271876 @default.
• W2127271876 citedByCount "85" @default.
• W2127271876 countsByYear W21272718762012 @default.
• W2127271876 countsByYear W21272718762013 @default.
• W2127271876 countsByYear W21272718762014 @default.
• W2127271876 countsByYear W21272718762015 @default.
• W2127271876 countsByYear W21272718762016 @default.
• W2127271876 countsByYear W21272718762017 @default.
• W2127271876 countsByYear W21272718762018 @default.
• W2127271876 countsByYear W21272718762019 @default.
• W2127271876 countsByYear W21272718762020 @default.
• W2127271876 countsByYear W21272718762021 @default.
• W2127271876 countsByYear W21272718762022 @default.
• W2127271876 countsByYear W21272718762023 @default.
• W2127271876 crossrefType "journal-article" @default.
• W2127271876 hasAuthorship W2127271876A5007063454 @default.
• W2127271876 hasAuthorship W2127271876A5064083499 @default.
• W2127271876 hasBestOaLocation W21272718762 @default.
• W2127271876 hasConcept C123321153 @default.
• W2127271876 hasConcept C136764020 @default.
• W2127271876 hasConcept C169586020 @default.
• W2127271876 hasConcept C181199279 @default.
• W2127271876 hasConcept C192989942 @default.
• W2127271876 hasConcept C2776414213 @default.
• W2127271876 hasConcept C2776694085 @default.
• W2127271876 hasConcept C2779932687 @default.
• W2127271876 hasConcept C2780456651 @default.
• W2127271876 hasConcept C2781092759 @default.
• W2127271876 hasConcept C2781320022 @default.
• W2127271876 hasConcept C2911037157 @default.
• W2127271876 hasConcept C41008148 @default.
• W2127271876 hasConcept C54355233 @default.

• next