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- W2127291289 abstract "Bioavailability of danazol-hydroxypropyl-β-cyclodextrin complex was investigated in rats and dogs using different routes of administration. The complex was administered buccally in an aqueous solution form to rats in which the esophagus had been ligated to prevent swallowing of the complex, while oral administration was by gastric gavage. In dogs, the complex was administered buccally in the form of rapidly dissolving adhesive patch formulation, and orally in the form of hard gelatin capsules. Buccal absorption of the complex was evaluated in an attempt to bypass presystemic elimination. Buccal absorption of danazol in rats was slow and mean plasma concentration exhibited a plateau for 5 h. However, the extent of absorption was higher than the oral route, and bioavailability was 186% relative to oral administration. The absolute bioavailability was 26.4% indicating incomplete absorption of the complex after buccal administration. Plasma profiles and pharmacokinetic parameters obtained in dogs were similar in the orally and buccally administered doses, suggesting that drug release from the buccal patch was not slow enough and the drug was consequently swallowed rather than absorbed across the buccal mucosa." @default.
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- W2127291289 date "1996-12-01" @default.
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- W2127291289 title "Bioavailability of danazol-hydroxypropyl-β-cylodextrin complex by different routes of administration" @default.
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- W2127291289 doi "https://doi.org/10.1016/s0378-5173(96)04763-1" @default.
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