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• W2127297869 endingPage "304" @default.
• W2127297869 startingPage "299" @default.
• W2127297869 abstract "Abstract Allogeneic hematopoietic stem cell transplantation (allogeneic HSCT) remains a curative treatment for hematological malignancies resistant to other treatment approaches through the unique GVL effect. However, relapse remains a major cause of treatment failure after allogeneic HSCT for patients with high-risk hematological malignancies. Further improvements in exploiting the GVL effect to prevent relapse in high-risk leukemias while minimizing toxicity have focused on the use of targeted antileukemic immunotherapy. These strategies include methods to boost the GVL effect with leukemia vaccines or the adoptive transfer of leukemia-specific lymphocytes. Vaccines can be classified as those against defined antigens such as minor histocompatibility antigens (mHags) or leukemia-associated antigens (PR1, WT1, and BCR-ABL) and those that have broad “antileukemic” activity such as engineered irradiated leukemia cells or leukemia-derived dendritic cells (DCs). The unique posttransplantation milieu, which is characterized by lymphopenia, regulatory T-cell depletion, and the release of growth factors, provides a unique opportunity for effective antitumor immunotherapy and augmenting specific GVL responses. This review focuses on approaches to enhancimg the GVL response by combining allogeneic HSCT with vaccination." @default.
• W2127297869 created "2016-06-24" @default.
• W2127297869 creator A5007244861 @default.
• W2127297869 date "2011-12-10" @default.
• W2127297869 modified "2023-10-16" @default.
• W2127297869 title "Posttransplantation Vaccination: Concepts Today and on the Horizon" @default.
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• W2127297869 doi "https://doi.org/10.1182/asheducation-2011.1.299" @default.
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