FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127305145> ?p ?o ?g. }

• W2127305145 endingPage "1111" @default.
• W2127305145 startingPage "1096" @default.
• W2127305145 abstract "CD8+ T-cell apoptosis is essential for the contraction phase of the immune response, yet the initiating signals and precise pathways involved are unresolved. The ST3Gal-I sialyltransferase is a candidate mechanistic component and catalyzes sialic acid addition to core 1 O-glycans during protein O glycosylation. ST3Gal-I inactivation or enzymatic removal of its product renders CD8+ T cells, but not CD4+ T cells, susceptible to apoptosis by differential cross-linking of O-glycoproteins in the absence of interleukin-2 and T-cell receptor (TCR) signaling. This results in caspase activation, DNA fragmentation, and phosphatidylserine externalization prior to cell death. We further show that ST3Gal-I function is regulated by a posttranscriptional mechanism operating distal to Golgi core 2 O glycosylation and is invariably linked to CD8+ T-cell contraction following viral (lymphocytic choriomeningitis virus) infection and bacterial (staphylococcal enterotoxin B) antigen immunization. The mechanism does not involve the ST3Gal-I substrate CD43 or core 2 O-glycan induction and overcomes the ability of Bcl-2 to inhibit the contraction phase in vivo. Loss of ST3Gal-I function further reduces Bim-deficient CD8+ T-cell accumulation without diminishing apoptotic sensitivity. We propose that an endogenous lectin activates an apoptotic pathway constructed in CD8+ T cells following TCR stimulation and enables contraction upon attenuation of immune signaling." @default.
• W2127305145 created "2016-06-24" @default.
• W2127305145 creator A5022635870 @default.
• W2127305145 creator A5054758763 @default.
• W2127305145 creator A5091291146 @default.
• W2127305145 date "2007-02-01" @default.
• W2127305145 modified "2023-10-18" @default.
• W2127305145 title "Structural and Mechanistic Features of Protein O Glycosylation Linked to CD8⁺ T-Cell Apoptosis" @default.
• W2127305145 cites W1503857509 @default.
• W2127305145 cites W1511676968 @default.
• W2127305145 cites W1522831768 @default.
• W2127305145 cites W1530982587 @default.
• W2127305145 cites W1539296097 @default.
• W2127305145 cites W1550866124 @default.
• W2127305145 cites W1562001883 @default.
• W2127305145 cites W1563776060 @default.
• W2127305145 cites W1585589080 @default.
• W2127305145 cites W1586958533 @default.
• W2127305145 cites W1735617490 @default.
• W2127305145 cites W1780524789 @default.
• W2127305145 cites W1925161599 @default.
• W2127305145 cites W1964850706 @default.
• W2127305145 cites W1967297513 @default.
• W2127305145 cites W1971319214 @default.
• W2127305145 cites W1974734422 @default.
• W2127305145 cites W1974906492 @default.
• W2127305145 cites W1989706412 @default.
• W2127305145 cites W1994018335 @default.
• W2127305145 cites W1998690402 @default.
• W2127305145 cites W2005493191 @default.
• W2127305145 cites W2007476453 @default.
• W2127305145 cites W2007671824 @default.
• W2127305145 cites W2021051229 @default.
• W2127305145 cites W2021362028 @default.
• W2127305145 cites W2022030273 @default.
• W2127305145 cites W2022684550 @default.
• W2127305145 cites W2024191848 @default.
• W2127305145 cites W2026069193 @default.
• W2127305145 cites W2030480585 @default.
• W2127305145 cites W2032592355 @default.
• W2127305145 cites W2042519375 @default.
• W2127305145 cites W2044117228 @default.
• W2127305145 cites W2052919634 @default.
• W2127305145 cites W2065512783 @default.
• W2127305145 cites W2069079409 @default.
• W2127305145 cites W2069340283 @default.
• W2127305145 cites W2069426612 @default.
• W2127305145 cites W2070820426 @default.
• W2127305145 cites W2071909988 @default.
• W2127305145 cites W2072100234 @default.
• W2127305145 cites W2079395328 @default.
• W2127305145 cites W2087501355 @default.
• W2127305145 cites W2088801927 @default.
• W2127305145 cites W2100368894 @default.
• W2127305145 cites W2111536196 @default.
• W2127305145 cites W2113132053 @default.
• W2127305145 cites W2129674168 @default.
• W2127305145 cites W2130630186 @default.
• W2127305145 cites W2131748930 @default.
• W2127305145 cites W2132224394 @default.
• W2127305145 cites W2138235536 @default.
• W2127305145 cites W2140489687 @default.
• W2127305145 cites W2141726017 @default.
• W2127305145 cites W2145341441 @default.
• W2127305145 cites W2150631671 @default.
• W2127305145 cites W2155658028 @default.
• W2127305145 cites W2157740207 @default.
• W2127305145 cites W2159531745 @default.
• W2127305145 cites W2162509295 @default.
• W2127305145 cites W2167052148 @default.
• W2127305145 cites W3025507454 @default.
• W2127305145 cites W4211059834 @default.
• W2127305145 doi "https://doi.org/10.1128/mcb.01750-06" @default.
• W2127305145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1800694" @default.
• W2127305145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17101770" @default.
• W2127305145 hasPublicationYear "2007" @default.
• W2127305145 type Work @default.
• W2127305145 sameAs 2127305145 @default.
• W2127305145 citedByCount "49" @default.
• W2127305145 countsByYear W21273051452012 @default.
• W2127305145 countsByYear W21273051452013 @default.
• W2127305145 countsByYear W21273051452014 @default.
• W2127305145 countsByYear W21273051452016 @default.
• W2127305145 countsByYear W21273051452017 @default.
• W2127305145 countsByYear W21273051452018 @default.
• W2127305145 countsByYear W21273051452019 @default.
• W2127305145 countsByYear W21273051452020 @default.
• W2127305145 countsByYear W21273051452021 @default.
• W2127305145 countsByYear W21273051452022 @default.
• W2127305145 countsByYear W21273051452023 @default.
• W2127305145 crossrefType "journal-article" @default.
• W2127305145 hasAuthorship W2127305145A5022635870 @default.
• W2127305145 hasAuthorship W2127305145A5054758763 @default.
• W2127305145 hasAuthorship W2127305145A5091291146 @default.
• W2127305145 hasBestOaLocation W21273051451 @default.
• W2127305145 hasConcept C153911025 @default.
• W2127305145 hasConcept C154317977 @default.
• W2127305145 hasConcept C167672396 @default.

• next