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• W2127307448 abstract "The orderly expression of specific genes is the basis for cell differentiation. Saccharomyces cerevisiae has two haploid mating types, a and α cells, in which the mating-specific genes are differentially expressed. When a and α cells are committed to mate, their growth is arrested. Here we show that a cryptic polyadenylation site is present inside the coding region of the a-specific STE2 gene, encoding the receptor for the α-factor. The two cell types produce an incomplete STE2 transcript, but only a cells generate full-length STE2 mRNA. We eliminated the cryptic poly(A) signal, thereby allowing the production of a complete STE2 mRNA in α cells. We mutagenized α cells and isolated a mutant producing full-length STE2 mRNA. The mutation occurred in the ITC1 gene, whose product, together with the product of ISW2, is known to repress STE2 transcriptional initiation. We propose that the regulation of the yeast mating genes is achieved through a concerted mechanism involving transcriptional and posttranscriptional events. In particular, the early poly(A) site in STE2 could contribute to a complete shutoff of its expression in α cells, avoiding autocrine activation and growth arrest. Remarkably, no cryptic poly(A) sites are present in the a-factor receptor STE3 gene, indicating that S. cerevisiae has devised different strategies to regulate the two receptor genes. It is predictable that a correlation between the repression of a gene and the presence of a cryptic poly(A) site could also be found in other organisms, especially when expression of that gene may be harmful." @default.
• W2127307448 created "2016-06-24" @default.
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• W2127307448 date "2011-10-03" @default.
• W2127307448 modified "2023-10-17" @default.
• W2127307448 title "Yeast pheromone receptor genes <i>STE2</i> and <i>STE3</i> are differently regulated at the transcription and polyadenylation level" @default.
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• W2127307448 doi "https://doi.org/10.1073/pnas.1114648108" @default.
• W2127307448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3193217" @default.
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