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• W2127320439 endingPage "402" @default.
• W2127320439 startingPage "373" @default.
• W2127320439 abstract "The ability of the liver to regenerate after parenchymal damage is usually accomplished by the ephemeral entry of normally proliferatively quiescent (G0) hepatocytes into the cell cycle. However, when hepatocyte regeneration is defective, arborizing ductules which are continuous with the biliary tree, proliferate and migrate into the surrounding parenchyma. In man these biliary cells have variously been referred to as ductular structures, neoductules and neocholangioles, and have been observed in many forms of chronic liver disease, including cancer. In experimental animals similar ductal cells are usually called oval cells, and their association with defective regeneration has led to the belief that these cells represent a progenitor cell population. Oval cells are thought to take over the burden of regenerative growth after substantial hepatocyte loss, suggesting that they are the progeny of facultative stem cells. The liver is not, however, generally considered as a stem cell-fed hierarchy, although this is disputed by others. Despite this, the subject of oval cells has aroused intense interest as these cells may represent a target population for hepatic carcinogens, and they may be useful vehicles for ex vivo gene therapy. This review proposes that the liver does harbour stem cells which are located throughout the biliary epithelium, and that oval cells represent the progeny of these stem cells and function as an amplification compartment for the generation of 'new' hepatocytes. This is a conditional process which only occurs when the regenerative capacity of hepatocytes is overwhelmed and thus, unlike the intestinal epithelium, the liver is not behaving as a classical continually renewing stem cell-fed lineage. We focus on the biliary network, not merely as a conduit for bile, but also as a cell compartment with the potential to proliferate under appropriate conditions and give rise to fully differentiated hepatocytes and other cell types." @default.
• W2127320439 created "2016-06-24" @default.
• W2127320439 creator A5016973766 @default.
• W2127320439 creator A5043821826 @default.
• W2127320439 creator A5059077571 @default.
• W2127320439 date "1996-07-01" @default.
• W2127320439 modified "2023-09-25" @default.
• W2127320439 title "Pluripotential liver stem cells: facultative stem cells located in the biliary tree" @default.
• W2127320439 cites W1514235737 @default.
• W2127320439 cites W1702287731 @default.
• W2127320439 cites W1786861597 @default.
• W2127320439 cites W1823130351 @default.
• W2127320439 cites W1968391842 @default.
• W2127320439 cites W1972487225 @default.
• W2127320439 cites W1973657908 @default.
• W2127320439 cites W1973997143 @default.
• W2127320439 cites W1974586745 @default.
• W2127320439 cites W1976332957 @default.
• W2127320439 cites W1978349753 @default.
• W2127320439 cites W1978507181 @default.
• W2127320439 cites W1980938275 @default.
• W2127320439 cites W1981112337 @default.
• W2127320439 cites W1983755961 @default.
• W2127320439 cites W1984393404 @default.
• W2127320439 cites W1985400766 @default.
• W2127320439 cites W1989815162 @default.
• W2127320439 cites W1997100869 @default.
• W2127320439 cites W2000830487 @default.
• W2127320439 cites W2007094387 @default.
• W2127320439 cites W2009848160 @default.
• W2127320439 cites W2010081432 @default.
• W2127320439 cites W2015017222 @default.
• W2127320439 cites W2016693266 @default.
• W2127320439 cites W2020747990 @default.
• W2127320439 cites W2022217882 @default.
• W2127320439 cites W2022766129 @default.
• W2127320439 cites W2024721720 @default.
• W2127320439 cites W2034483815 @default.
• W2127320439 cites W2037377193 @default.
• W2127320439 cites W2039618230 @default.
• W2127320439 cites W2042213831 @default.
• W2127320439 cites W2043344911 @default.
• W2127320439 cites W2044423704 @default.
• W2127320439 cites W2046083532 @default.
• W2127320439 cites W2051172626 @default.
• W2127320439 cites W2052764651 @default.
• W2127320439 cites W2060655489 @default.
• W2127320439 cites W2062372588 @default.
• W2127320439 cites W2062521096 @default.
• W2127320439 cites W2063529172 @default.
• W2127320439 cites W2064268635 @default.
• W2127320439 cites W2066644227 @default.
• W2127320439 cites W2071545773 @default.
• W2127320439 cites W2073808856 @default.
• W2127320439 cites W2074461807 @default.
• W2127320439 cites W2074966846 @default.
• W2127320439 cites W2076965242 @default.
• W2127320439 cites W2081631539 @default.
• W2127320439 cites W2084767118 @default.
• W2127320439 cites W2086781527 @default.
• W2127320439 cites W2088119816 @default.
• W2127320439 cites W2088394579 @default.
• W2127320439 cites W2089140170 @default.
• W2127320439 cites W2090497358 @default.
• W2127320439 cites W2091353697 @default.
• W2127320439 cites W2094133811 @default.
• W2127320439 cites W2095166272 @default.
• W2127320439 cites W2104856326 @default.
• W2127320439 cites W2109971285 @default.
• W2127320439 cites W2110229128 @default.
• W2127320439 cites W2110278880 @default.
• W2127320439 cites W2117113805 @default.
• W2127320439 cites W2121562333 @default.
• W2127320439 cites W2123601573 @default.
• W2127320439 cites W2129849944 @default.
• W2127320439 cites W2130157555 @default.
• W2127320439 cites W2136218955 @default.
• W2127320439 cites W2136873073 @default.
• W2127320439 cites W2141617559 @default.
• W2127320439 cites W2145980749 @default.
• W2127320439 cites W2147727142 @default.
• W2127320439 cites W2148459495 @default.
• W2127320439 cites W2162939439 @default.
• W2127320439 cites W2164204589 @default.
• W2127320439 cites W2164498029 @default.
• W2127320439 cites W2168362482 @default.
• W2127320439 cites W2169994464 @default.
• W2127320439 cites W2315457571 @default.
• W2127320439 cites W2316532201 @default.
• W2127320439 cites W2316743387 @default.
• W2127320439 cites W2316962700 @default.
• W2127320439 cites W2322839894 @default.
• W2127320439 cites W2331630900 @default.
• W2127320439 cites W2332056710 @default.
• W2127320439 cites W2332521194 @default.
• W2127320439 cites W2521880154 @default.
• W2127320439 cites W269467774 @default.
• W2127320439 cites W4234344930 @default.

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