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• W2127326179 endingPage "1477" @default.
• W2127326179 startingPage "1466" @default.
• W2127326179 abstract "Hyaluronan (HA) is a naturally occurring linear, negatively charged polysaccharide that plays a vital role in the organization and function of pericellular coats and extracellular matrices in vertebrates, and that is becoming increasingly popular in biomedical applications. To gain insight into the physical phenomena that govern the mechanical behavior of HA assemblies, we have studied the response of films of end-grafted HA to compression over a large range of ionic strength. Compression forces were measured as a function of the absolute distance between a colloidal probe and the planar surface on which the HA film was constructed, using a combined atomic force microscopy and reflection interference contrast microscopy setup. The HA films were well-defined in the sense that they are made of chains with a narrow size distribution that are grafted at controlled density to a solid support. Detailed comparison of the experimental data with analytical expressions derived from polymer and polyelectrolyte brush theory reveals that films of end-grafted HA behave as strongly charged polyelectrolyte brushes. To quantitatively reproduce the experimental data, intrinsic excluded volume interactions and chain stiffness of the polymer backbone must be taken into account. At low ionic strength, chains become almost fully stretched. In our experimental system, several micrometer thick films are formed that reach a hydration of up to 99.98%, and the brush thickness decreases by more than 5-fold with increasing ionic strength. More generally, the study provides quantitative theoretical predictions for the film thickness and compressive response as a function of HA length, grafting density and ionic strength." @default.
• W2127326179 created "2016-06-24" @default.
• W2127326179 creator A5011773061 @default.
• W2127326179 creator A5012633932 @default.
• W2127326179 creator A5046269328 @default.
• W2127326179 date "2012-04-25" @default.
• W2127326179 modified "2023-09-25" @default.
• W2127326179 title "Films of End-Grafted Hyaluronan Are a Prototype of a Brush of a Strongly Charged, Semiflexible Polyelectrolyte with Intrinsic Excluded Volume" @default.
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• W2127326179 doi "https://doi.org/10.1021/bm3001759" @default.
• W2127326179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22455455" @default.
• W2127326179 hasPublicationYear "2012" @default.
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