FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127329148> ?p ?o ?g. }

• W2127329148 endingPage "1460" @default.
• W2127329148 startingPage "1451" @default.
• W2127329148 abstract "Pancreatic ductal adenocarcinoma co-opts multiple cellular and extracellular mechanisms to create a complex cancer organ with an unusual proclivity for metastasis and resistance to therapy. Cell-autonomous events are essential for the initiation and maintenance of pancreatic ductal adenocarcinoma, but recent studies have implicated critical non-cell autonomous processes within the robust desmoplastic stroma that promote disease pathogenesis and resistance. Thus, non-malignant cells and associated factors are culprits in tumor growth, immunosuppression and invasion. However, even this increasing awareness of non-cell autonomous contributions to disease progression is tempered by the conflicting roles stromal elements can play. A greater understanding of stromal complexity and complicity has been aided in part by studies in highly faithful genetically engineered mouse models of pancreatic ductal adenocarcinoma. Insights gleaned from such studies are spurring the development of therapies designed to reengineer the pancreas cancer stroma and render it permissive to agents targeting cell-autonomous events or to reinstate immunosurveillance. Integrating conventional and immunological treatments in the context of stromal targeting may provide the key to a durable clinical impact on this formidable disease." @default.
• W2127329148 created "2016-06-24" @default.
• W2127329148 creator A5013925502 @default.
• W2127329148 creator A5014810863 @default.
• W2127329148 creator A5030463228 @default.
• W2127329148 creator A5079776393 @default.
• W2127329148 date "2014-06-07" @default.
• W2127329148 modified "2023-10-08" @default.
• W2127329148 title "Stromal reengineering to treat pancreas cancer" @default.
• W2127329148 cites W1501518736 @default.
• W2127329148 cites W1574254013 @default.
• W2127329148 cites W1669165205 @default.
• W2127329148 cites W1683802707 @default.
• W2127329148 cites W1925817305 @default.
• W2127329148 cites W1965891567 @default.
• W2127329148 cites W1966922635 @default.
• W2127329148 cites W1967215435 @default.
• W2127329148 cites W1967660850 @default.
• W2127329148 cites W1968144869 @default.
• W2127329148 cites W1971400930 @default.
• W2127329148 cites W1971447646 @default.
• W2127329148 cites W1973147485 @default.
• W2127329148 cites W1973647796 @default.
• W2127329148 cites W1977692898 @default.
• W2127329148 cites W1981471842 @default.
• W2127329148 cites W1984146357 @default.
• W2127329148 cites W1985780641 @default.
• W2127329148 cites W1986497348 @default.
• W2127329148 cites W1988474688 @default.
• W2127329148 cites W1989227645 @default.
• W2127329148 cites W1990983926 @default.
• W2127329148 cites W1992995822 @default.
• W2127329148 cites W1996912024 @default.
• W2127329148 cites W2000212143 @default.
• W2127329148 cites W2001378959 @default.
• W2127329148 cites W2003380614 @default.
• W2127329148 cites W2004150448 @default.
• W2127329148 cites W2008658155 @default.
• W2127329148 cites W2012652981 @default.
• W2127329148 cites W2015123389 @default.
• W2127329148 cites W2015919529 @default.
• W2127329148 cites W2016939812 @default.
• W2127329148 cites W2017893786 @default.
• W2127329148 cites W2018159884 @default.
• W2127329148 cites W2023776610 @default.
• W2127329148 cites W2025381786 @default.
• W2127329148 cites W2031960993 @default.
• W2127329148 cites W2032986552 @default.
• W2127329148 cites W2038918212 @default.
• W2127329148 cites W2042760078 @default.
• W2127329148 cites W2043991982 @default.
• W2127329148 cites W2044433401 @default.
• W2127329148 cites W2045356233 @default.
• W2127329148 cites W2045814042 @default.
• W2127329148 cites W2047203592 @default.
• W2127329148 cites W2047578760 @default.
• W2127329148 cites W2048253455 @default.
• W2127329148 cites W2050514979 @default.
• W2127329148 cites W2051517030 @default.
• W2127329148 cites W2051563649 @default.
• W2127329148 cites W2052617606 @default.
• W2127329148 cites W2054034979 @default.
• W2127329148 cites W2054738595 @default.
• W2127329148 cites W2055091294 @default.
• W2127329148 cites W2056646351 @default.
• W2127329148 cites W2057267126 @default.
• W2127329148 cites W2060656939 @default.
• W2127329148 cites W2062127942 @default.
• W2127329148 cites W2062265555 @default.
• W2127329148 cites W2062266078 @default.
• W2127329148 cites W2062873927 @default.
• W2127329148 cites W2063659536 @default.
• W2127329148 cites W2066135299 @default.
• W2127329148 cites W2068442933 @default.
• W2127329148 cites W2069169522 @default.
• W2127329148 cites W2069269337 @default.
• W2127329148 cites W2071462987 @default.
• W2127329148 cites W2074546881 @default.
• W2127329148 cites W2077569461 @default.
• W2127329148 cites W2085581142 @default.
• W2127329148 cites W2086834665 @default.
• W2127329148 cites W2087766713 @default.
• W2127329148 cites W2088110734 @default.
• W2127329148 cites W2088181957 @default.
• W2127329148 cites W2089232392 @default.
• W2127329148 cites W2089753996 @default.
• W2127329148 cites W2092100136 @default.
• W2127329148 cites W2097995306 @default.
• W2127329148 cites W2100252473 @default.
• W2127329148 cites W2100519108 @default.
• W2127329148 cites W2106775454 @default.
• W2127329148 cites W2107441200 @default.
• W2127329148 cites W2108114104 @default.
• W2127329148 cites W2111547416 @default.
• W2127329148 cites W2113320375 @default.
• W2127329148 cites W2113657892 @default.
• W2127329148 cites W2115359512 @default.
• W2127329148 cites W2117566184 @default.

• next