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- W2127338111 abstract "Chronic hepatitis B virus (HBV) infections may lead to severe diseases like liver cirrhosis or hepatocellular carcinoma (HCC). The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3'-region of all viral transcripts. The HPRE consists of three sub-elements alpha (nucleotides 1151-1346), beta1 (nucleotides 1347-1457) and beta2 (nucleotides 1458-1582), which confer together full export competence. Here, we present the NMR solution structure (pdb 2JYM) of the stem-loop alpha (SLalpha, nucleotides 1292-1321) located in the sub-element alpha. The SLalpha contains a CAGGC pentaloop highly conserved in hepatoviruses, which essentially adopts a CUNG-like tetraloop conformation. Furthermore, the SLalpha harbours a single bulged G residue flanked by A-helical regions. The structure is highly suggestive of serving two functions in the context of export of unspliced viral RNA: binding sterile alpha motif (SAM-) domain containing proteins and/or preventing the utilization of a 3'-splice site contained within SLalpha." @default.
- W2127338111 created "2016-06-24" @default.
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- W2127338111 creator A5073876133 @default.
- W2127338111 creator A5079981978 @default.
- W2127338111 creator A5081151332 @default.
- W2127338111 date "2008-02-07" @default.
- W2127338111 modified "2023-09-27" @default.
- W2127338111 title "Solution structure of stem-loop α of the hepatitis B virus post-transcriptional regulatory element" @default.
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- W2127338111 doi "https://doi.org/10.1093/nar/gkn006" @default.
- W2127338111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2275152" @default.
- W2127338111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18263618" @default.
- W2127338111 hasPublicationYear "2008" @default.
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