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- W2127350922 abstract "T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic inflammation in mice, and are associated with allergic disease in humans. It has not been determined whether Th9 cells express a characteristic transcriptional signature. In this study, we performed microarray analysis to identify genes enriched in Th9 cells compared with other Th subsets. This analysis defined a transcriptional regulatory network required for the expression of a subset of Th9-enriched genes. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor–like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes in both human and mouse T cells. The expression of BATF was increased in Th9 cultures derived from atopic infants compared with Th9 cultures from control infants. T cells deficient in BATF expression had a diminished capacity to promote allergic inflammation compared with wild-type controls. Moreover, mouse Th9 cells ectopically expressing BATF were more efficient at promoting allergic inflammation than control transduced cells. These data indicate that BATF is a central regulator of the Th9 phenotype and contributes to the development of allergic inflammation." @default.
- W2127350922 created "2016-06-24" @default.
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- W2127350922 date "2013-10-08" @default.
- W2127350922 modified "2023-09-30" @default.
- W2127350922 title "Th9 cell development requires a BATF-regulated transcriptional network" @default.
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- W2127350922 doi "https://doi.org/10.1172/jci69489" @default.
- W2127350922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3809790" @default.
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