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- W2127354313 abstract "Bacterial- and plant-derived immunotoxins have documented potential for treatment of cancer. We discuss Anthrax toxin, ribosome inactivating-toxins, such as saporin and ricin, and ADP-ribosylating toxins such as Diphtheria toxin and Pseudomonas exotoxin, with focus on the latter, which has been most thoroughly investigated. Regarding their potential as anticancer agents, critical issues such as immunogenicity and toxicity are outlined. We describe different generations of immunotoxins, the pathways for the delivery of the cytotoxic 'warheads', molecular parameters modulating efficacy, and combination therapy with other anticancer agents. Finally, we discuss deimmunization strategies based on the removal of B- and T-cell epitopes from the cytotoxic component, and highlight promising clinical proof-of-concept studies." @default.
- W2127354313 created "2016-06-24" @default.
- W2127354313 creator A5025299367 @default.
- W2127354313 creator A5055990904 @default.
- W2127354313 creator A5058855855 @default.
- W2127354313 creator A5073715309 @default.
- W2127354313 creator A5086158908 @default.
- W2127354313 creator A5089500666 @default.
- W2127354313 date "2014-03-19" @default.
- W2127354313 modified "2023-10-01" @default.
- W2127354313 title "Prospects of bacterial and plant protein-based immunotoxins for treatment of cancer." @default.
- W2127354313 cites W111956875 @default.
- W2127354313 cites W1237125621 @default.
- W2127354313 cites W1482431053 @default.
- W2127354313 cites W1515560810 @default.
- W2127354313 cites W1517716046 @default.
- W2127354313 cites W1540826012 @default.
- W2127354313 cites W1561227425 @default.
- W2127354313 cites W1569346530 @default.
- W2127354313 cites W1592698292 @default.
- W2127354313 cites W1607832269 @default.
- W2127354313 cites W1638217205 @default.
- W2127354313 cites W1641029843 @default.
- W2127354313 cites W1762888952 @default.
- W2127354313 cites W1822949416 @default.
- W2127354313 cites W1886985639 @default.
- W2127354313 cites W1895474562 @default.
- W2127354313 cites W1963659548 @default.
- W2127354313 cites W1965799366 @default.
- W2127354313 cites W1976801077 @default.
- W2127354313 cites W1976885142 @default.
- W2127354313 cites W1977122810 @default.
- W2127354313 cites W1978148288 @default.
- W2127354313 cites W1978599968 @default.
- W2127354313 cites W1978653793 @default.
- W2127354313 cites W1983159021 @default.
- W2127354313 cites W1989161548 @default.
- W2127354313 cites W1989269073 @default.
- W2127354313 cites W1992650953 @default.
- W2127354313 cites W1995910871 @default.
- W2127354313 cites W1999624685 @default.
- W2127354313 cites W2001385539 @default.
- W2127354313 cites W2001626604 @default.
- W2127354313 cites W2003935158 @default.
- W2127354313 cites W2004738840 @default.
- W2127354313 cites W2005951087 @default.
- W2127354313 cites W2006403834 @default.
- W2127354313 cites W2007336991 @default.
- W2127354313 cites W2009013652 @default.
- W2127354313 cites W2010260569 @default.
- W2127354313 cites W2010900024 @default.
- W2127354313 cites W2011601805 @default.
- W2127354313 cites W2013204504 @default.
- W2127354313 cites W2013343838 @default.
- W2127354313 cites W2021404182 @default.
- W2127354313 cites W2026406389 @default.
- W2127354313 cites W2028382123 @default.
- W2127354313 cites W2034500754 @default.
- W2127354313 cites W2042711924 @default.
- W2127354313 cites W2046065180 @default.
- W2127354313 cites W2046092294 @default.
- W2127354313 cites W2046307995 @default.
- W2127354313 cites W2049099826 @default.
- W2127354313 cites W2049762173 @default.
- W2127354313 cites W2056131772 @default.
- W2127354313 cites W2056239031 @default.
- W2127354313 cites W2056498488 @default.
- W2127354313 cites W2062348697 @default.
- W2127354313 cites W2065248620 @default.
- W2127354313 cites W2069459218 @default.
- W2127354313 cites W2072767834 @default.
- W2127354313 cites W2073651499 @default.
- W2127354313 cites W2074622213 @default.
- W2127354313 cites W2075930797 @default.
- W2127354313 cites W2076052138 @default.
- W2127354313 cites W2083670089 @default.
- W2127354313 cites W2092764309 @default.
- W2127354313 cites W2096913348 @default.
- W2127354313 cites W2099149619 @default.
- W2127354313 cites W2099348990 @default.
- W2127354313 cites W2099718405 @default.
- W2127354313 cites W2100764983 @default.
- W2127354313 cites W2101883285 @default.
- W2127354313 cites W2102743505 @default.
- W2127354313 cites W2104235597 @default.
- W2127354313 cites W2106443011 @default.
- W2127354313 cites W2106731734 @default.
- W2127354313 cites W2107261030 @default.
- W2127354313 cites W2110710051 @default.
- W2127354313 cites W2110964568 @default.
- W2127354313 cites W2111344966 @default.
- W2127354313 cites W2111618277 @default.
- W2127354313 cites W2113530505 @default.
- W2127354313 cites W2117076484 @default.
- W2127354313 cites W2117692326 @default.
- W2127354313 cites W2121252421 @default.
- W2127354313 cites W2122828730 @default.
- W2127354313 cites W2122999961 @default.