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- W2127377584 abstract "Abstract Progress in the photodynamic therapy (PDT) of cancer should benefit from a rationale to predict the most efficient of a series of photosensitizers that strongly absorb light in the phototherapeutic window (650–800 nm) and efficiently generate reactive oxygen species (ROS=singlet oxygen and oxygen‐centered radicals). We show that the ratios between the triplet photosensitizer–O 2 interaction rate constant ( k D ) and the photosensitizer decomposition rate constant ( k d ), k D / k d , determine the relative photodynamic activities of photosensitizers against various cancer cells. The same efficacy trend is observed in vivo with DBA/2 mice bearing S91 melanoma tumors. The PDT efficacy intimately depends on the dynamics of photosensitizer–oxygen interactions: charge transfer to molecular oxygen with generation of both singlet oxygen and superoxide ion (high k D ) must be tempered by photostability (low k d ). These properties depend on the oxidation potential of the photosensitizer and are suitably combined in a new fluorinated sulfonamide bacteriochlorin, motivated by the rationale." @default.
- W2127377584 created "2016-06-24" @default.
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- W2127377584 date "2014-03-18" @default.
- W2127377584 modified "2023-10-18" @default.
- W2127377584 title "Photodynamic Therapy Efficacy Enhanced by Dynamics: The Role of Charge Transfer and Photostability in the Selection of Photosensitizers" @default.
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- W2127377584 doi "https://doi.org/10.1002/chem.201304202" @default.