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- W2127388620 abstract "To investigate the effect of WISP2 in vivo, we generated a transgenic mouse model overexpressing WISP2 in the adipose tissue under the aP2-promoter. We found WISP2 to be secreted by the adipose tissue and present in serum. The mice had a similar body weight but were characterized by improved insulin sensitivity, increased circulating levels of adiponectin and the novel FAHFA lipids and increased Glut4 in both adipose tissue and skeletal muscle. They were also characterized by markers of increased mesenchymal stem cell growth and development with a markedly expanded BAT, a ”healthy” hyperplastic subcutaneous adipose tissue and increased lean body mass. Serum from the Tg mice also increased the proliferation of both brown adipose precursor cells and the mesenchymal stem-like CH3T101/2 cells and this was inhibited by adding specific anti-WISP2 monoclonal antibodies to the serum. Taken together, WISP2 is a novel secreted autocrine/endocrine regulator of mesenchymal stem cell growth and proliferation as well as their adipogenic commitment. There is important cross-talk between WISP2 and BMP4 in the regulation of adipogenic commitment and differentiation and BMP4 is also a regulator of WISP2 transcriptional activation. WISP2 is a novel target in hypertrophic obesity and the Metabolic Syndrome." @default.
- W2127388620 created "2016-06-24" @default.
- W2127388620 creator A5054209423 @default.
- W2127388620 date "2015-02-27" @default.
- W2127388620 modified "2023-09-27" @default.
- W2127388620 title "WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance" @default.
- W2127388620 cites W1886903604 @default.
- W2127388620 cites W1925481732 @default.
- W2127388620 cites W1965079305 @default.
- W2127388620 cites W1967131493 @default.
- W2127388620 cites W1967183306 @default.
- W2127388620 cites W1967717006 @default.
- W2127388620 cites W1970203534 @default.
- W2127388620 cites W1970636319 @default.
- W2127388620 cites W1971226856 @default.
- W2127388620 cites W1973345981 @default.
- W2127388620 cites W1981525131 @default.
- W2127388620 cites W1982190993 @default.
- W2127388620 cites W1984095706 @default.
- W2127388620 cites W1986131332 @default.
- W2127388620 cites W1986251617 @default.
- W2127388620 cites W1988483859 @default.
- W2127388620 cites W1988518646 @default.
- W2127388620 cites W1989020172 @default.
- W2127388620 cites W1991961067 @default.
- W2127388620 cites W1998414295 @default.
- W2127388620 cites W1999618694 @default.
- W2127388620 cites W1999986580 @default.
- W2127388620 cites W2006419043 @default.
- W2127388620 cites W2006547120 @default.
- W2127388620 cites W2007308792 @default.
- W2127388620 cites W2008092961 @default.
- W2127388620 cites W2008150005 @default.
- W2127388620 cites W2012655679 @default.
- W2127388620 cites W2013246050 @default.
- W2127388620 cites W2016108853 @default.
- W2127388620 cites W2023447877 @default.
- W2127388620 cites W2025152562 @default.
- W2127388620 cites W2027753197 @default.
- W2127388620 cites W2027849612 @default.
- W2127388620 cites W2028916695 @default.
- W2127388620 cites W2029194147 @default.
- W2127388620 cites W2029746173 @default.
- W2127388620 cites W2032020008 @default.
- W2127388620 cites W2035489548 @default.
- W2127388620 cites W2037978897 @default.
- W2127388620 cites W2043129312 @default.
- W2127388620 cites W2044021940 @default.
- W2127388620 cites W2044758669 @default.
- W2127388620 cites W2051211373 @default.
- W2127388620 cites W2051993213 @default.
- W2127388620 cites W2052045899 @default.
- W2127388620 cites W2053017040 @default.
- W2127388620 cites W2053617341 @default.
- W2127388620 cites W2053780981 @default.
- W2127388620 cites W2055094070 @default.
- W2127388620 cites W2058020690 @default.
- W2127388620 cites W2058473208 @default.
- W2127388620 cites W2058779977 @default.
- W2127388620 cites W2059114286 @default.
- W2127388620 cites W2059992589 @default.
- W2127388620 cites W2060163874 @default.
- W2127388620 cites W2061144747 @default.
- W2127388620 cites W2062597305 @default.
- W2127388620 cites W2062800428 @default.
- W2127388620 cites W2066280893 @default.
- W2127388620 cites W2069760818 @default.
- W2127388620 cites W2070567106 @default.
- W2127388620 cites W2070745109 @default.
- W2127388620 cites W2071692398 @default.
- W2127388620 cites W2071728131 @default.
- W2127388620 cites W2072087746 @default.
- W2127388620 cites W2074814691 @default.
- W2127388620 cites W2079711850 @default.
- W2127388620 cites W2079819294 @default.
- W2127388620 cites W2080610855 @default.
- W2127388620 cites W2090482643 @default.
- W2127388620 cites W2090693843 @default.
- W2127388620 cites W2091930065 @default.
- W2127388620 cites W2092494241 @default.
- W2127388620 cites W2093869147 @default.
- W2127388620 cites W2097899015 @default.
- W2127388620 cites W2099007621 @default.
- W2127388620 cites W2099164108 @default.
- W2127388620 cites W2101099513 @default.
- W2127388620 cites W2101304778 @default.
- W2127388620 cites W2101492172 @default.
- W2127388620 cites W2102313291 @default.
- W2127388620 cites W2103370215 @default.
- W2127388620 cites W2104085328 @default.
- W2127388620 cites W2104827888 @default.
- W2127388620 cites W2105912552 @default.
- W2127388620 cites W2106007814 @default.
- W2127388620 cites W2106690226 @default.
- W2127388620 cites W2107400488 @default.
- W2127388620 cites W2107732097 @default.
- W2127388620 cites W2108452257 @default.
- W2127388620 cites W210907777 @default.
- W2127388620 cites W2110330424 @default.
- W2127388620 cites W2112278084 @default.