FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127399265> ?p ?o ?g. }

• W2127399265 endingPage "C464" @default.
• W2127399265 startingPage "C457" @default.
• W2127399265 abstract "Shockwaves elicited by transient pressure disturbances are used to treat musculoskeletal disorders. Previous research has shown that shockwave treatment affects T-cell function, enhancing T-cell proliferation and IL-2 expression by activating p38 mitogen-activated protein kinase (MAPK) signaling. Here we investigated the signaling pathway by which shockwaves mediate p38 MAPK phosphorylation. We found that shockwaves at an intensity of 0.18 mJ/mm 2 induce the release of extracellular ATP from human Jurkat T-cells at least in part by affecting cell viability. ATP released into the extracellular space stimulates P2X7-type purinergic receptors that induce the activation of p38 MAPK and of focal adhesion kinase (FAK) by phosphorylation on residues Tyr397 and Tyr576/577. Elimination of released ATP with apyrase or inhibition of P2X7 receptors with the antagonists KN-62 or suramin significantly weakens FAK phosphorylation, p38 MAPK activation, IL-2 expression, and T-cell proliferation. Conversely, addition of exogenous ATP causes phosphorylation of FAK and p38 MAPK. Silencing of FAK expression also reduces these cell responses to shockwave treatment. We conclude that shockwaves enhance p38 MAPK activation, IL-2 expression, and T-cell proliferation via the release of cellular ATP and feedback mechanisms that involve P2X7 receptor activation and FAK phosphorylation." @default.
• W2127399265 created "2016-06-24" @default.
• W2127399265 creator A5010491128 @default.
• W2127399265 creator A5012136163 @default.
• W2127399265 creator A5022958901 @default.
• W2127399265 creator A5024124338 @default.
• W2127399265 creator A5026398937 @default.
• W2127399265 creator A5046869052 @default.
• W2127399265 creator A5054707172 @default.
• W2127399265 creator A5068425513 @default.
• W2127399265 date "2010-03-01" @default.
• W2127399265 modified "2023-10-18" @default.
• W2127399265 title "Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation" @default.
• W2127399265 cites W1532386517 @default.
• W2127399265 cites W1599213556 @default.
• W2127399265 cites W1816235302 @default.
• W2127399265 cites W1964663565 @default.
• W2127399265 cites W1969342647 @default.
• W2127399265 cites W1975685152 @default.
• W2127399265 cites W1980096477 @default.
• W2127399265 cites W1983504852 @default.
• W2127399265 cites W1987062630 @default.
• W2127399265 cites W1987455208 @default.
• W2127399265 cites W1997158886 @default.
• W2127399265 cites W1997360766 @default.
• W2127399265 cites W1998229588 @default.
• W2127399265 cites W1998611272 @default.
• W2127399265 cites W2005158758 @default.
• W2127399265 cites W2008602135 @default.
• W2127399265 cites W2014830942 @default.
• W2127399265 cites W2017917336 @default.
• W2127399265 cites W2018507889 @default.
• W2127399265 cites W2019443912 @default.
• W2127399265 cites W2020358112 @default.
• W2127399265 cites W2028364766 @default.
• W2127399265 cites W2028714075 @default.
• W2127399265 cites W2030400632 @default.
• W2127399265 cites W2031434196 @default.
• W2127399265 cites W2039274143 @default.
• W2127399265 cites W2043998158 @default.
• W2127399265 cites W2052553464 @default.
• W2127399265 cites W2055593439 @default.
• W2127399265 cites W2068837653 @default.
• W2127399265 cites W2075744025 @default.
• W2127399265 cites W2082986119 @default.
• W2127399265 cites W2083034122 @default.
• W2127399265 cites W2085162472 @default.
• W2127399265 cites W2090956512 @default.
• W2127399265 cites W2091222720 @default.
• W2127399265 cites W2099363887 @default.
• W2127399265 cites W2101516208 @default.
• W2127399265 cites W2103181800 @default.
• W2127399265 cites W2104082830 @default.
• W2127399265 cites W2105174816 @default.
• W2127399265 cites W2137141750 @default.
• W2127399265 cites W2137476452 @default.
• W2127399265 cites W2144280781 @default.
• W2127399265 cites W2155733717 @default.
• W2127399265 cites W2170689840 @default.
• W2127399265 cites W70414729 @default.
• W2127399265 doi "https://doi.org/10.1152/ajpcell.00342.2009" @default.
• W2127399265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4631534" @default.
• W2127399265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19889958" @default.
• W2127399265 hasPublicationYear "2010" @default.
• W2127399265 type Work @default.
• W2127399265 sameAs 2127399265 @default.
• W2127399265 citedByCount "45" @default.
• W2127399265 countsByYear W21273992652012 @default.
• W2127399265 countsByYear W21273992652013 @default.
• W2127399265 countsByYear W21273992652014 @default.
• W2127399265 countsByYear W21273992652015 @default.
• W2127399265 countsByYear W21273992652016 @default.
• W2127399265 countsByYear W21273992652017 @default.
• W2127399265 countsByYear W21273992652018 @default.
• W2127399265 countsByYear W21273992652019 @default.
• W2127399265 countsByYear W21273992652020 @default.
• W2127399265 countsByYear W21273992652021 @default.
• W2127399265 countsByYear W21273992652022 @default.
• W2127399265 countsByYear W21273992652023 @default.
• W2127399265 crossrefType "journal-article" @default.
• W2127399265 hasAuthorship W2127399265A5010491128 @default.
• W2127399265 hasAuthorship W2127399265A5012136163 @default.
• W2127399265 hasAuthorship W2127399265A5022958901 @default.
• W2127399265 hasAuthorship W2127399265A5024124338 @default.
• W2127399265 hasAuthorship W2127399265A5026398937 @default.
• W2127399265 hasAuthorship W2127399265A5046869052 @default.
• W2127399265 hasAuthorship W2127399265A5054707172 @default.
• W2127399265 hasAuthorship W2127399265A5068425513 @default.
• W2127399265 hasBestOaLocation W21273992652 @default.
• W2127399265 hasConcept C11960822 @default.
• W2127399265 hasConcept C151166631 @default.
• W2127399265 hasConcept C170493617 @default.
• W2127399265 hasConcept C179464577 @default.
• W2127399265 hasConcept C184235292 @default.
• W2127399265 hasConcept C185592680 @default.
• W2127399265 hasConcept C203014093 @default.
• W2127399265 hasConcept C2776090121 @default.
• W2127399265 hasConcept C2776182878 @default.

• next