FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127403785> ?p ?o ?g. }

• W2127403785 endingPage "1121" @default.
• W2127403785 startingPage "1112" @default.
• W2127403785 abstract "Evidence suggests that the rate at which intravenous anesthetics are infused may influence their plasma-effect site equilibration. The authors used five different rates of propofol administration to test the hypothesis that different sedation endpoints occur at the same effect site propofol concentration, independent of the infusion rate. The authors concurrently evaluated the automated responsiveness monitor (ARM) against other sedation measures and the propofol effect site concentration.With Human Studies Committee approval, 18 healthy volunteers received five consecutive target-controlled propofol infusions. During each infusion, the effect site concentration was increased by a rate of 0.1, 0.3, 0.5, 0.7, or 0.9 microg . ml . min. The Bispectral Index and ARM were recorded at frequent intervals. The times of syringe drop and loss and recovery of responsiveness were noted. Pharmacokinetic and pharmacodynamic modeling was performed using NONMEM.When the correct rate of plasma-effect site equilibration was determined for each individual (plasma-effect site equilibration = 0.17 min, time to peak effect = 2.7 min), the effect site concentrations associated with each clinical measure were not affected by the rate of increase of effect site propofol concentration. ARM correlated with all clinical measures of drug effect. Subjects invariably stopped responding to ARM at lower effect site propofol concentrations than those associated with loss of responsiveness.: Population-based pharmacokinetics, combined with real-time electroencephalographic measures of drug effect, may provide a means to individualize pharmacodynamic modeling during target-controlled drug delivery. ARM seems useful as an automated measure of sedation and may provide the basis for automated monitoring and titration of sedation for a propofol delivery system." @default.
• W2127403785 created "2016-06-24" @default.
• W2127403785 creator A5018403068 @default.
• W2127403785 creator A5042996287 @default.
• W2127403785 creator A5064307261 @default.
• W2127403785 creator A5076462126 @default.
• W2127403785 creator A5084632357 @default.
• W2127403785 date "2004-11-01" @default.
• W2127403785 modified "2023-09-26" @default.
• W2127403785 title "Induction Speed Is Not a Determinant of Propofol Pharmacodynamics" @default.
• W2127403785 cites W123609371 @default.
• W2127403785 cites W1970467392 @default.
• W2127403785 cites W1970765850 @default.
• W2127403785 cites W1980959248 @default.
• W2127403785 cites W1985858036 @default.
• W2127403785 cites W1988207262 @default.
• W2127403785 cites W1996540722 @default.
• W2127403785 cites W2003076007 @default.
• W2127403785 cites W2029714422 @default.
• W2127403785 cites W2032786567 @default.
• W2127403785 cites W2039022988 @default.
• W2127403785 cites W2043742363 @default.
• W2127403785 cites W2046917594 @default.
• W2127403785 cites W2049349314 @default.
• W2127403785 cites W2051697200 @default.
• W2127403785 cites W2055618961 @default.
• W2127403785 cites W2084406991 @default.
• W2127403785 cites W2093234745 @default.
• W2127403785 cites W2096043598 @default.
• W2127403785 cites W2099979900 @default.
• W2127403785 cites W2106727887 @default.
• W2127403785 cites W2115473091 @default.
• W2127403785 cites W2120534719 @default.
• W2127403785 cites W2122171313 @default.
• W2127403785 cites W2124175280 @default.
• W2127403785 cites W2134665126 @default.
• W2127403785 cites W2134706150 @default.
• W2127403785 cites W2156376198 @default.
• W2127403785 cites W2324227497 @default.
• W2127403785 cites W240539887 @default.
• W2127403785 cites W2021678846 @default.
• W2127403785 doi "https://doi.org/10.1097/00000542-200411000-00010" @default.
• W2127403785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1249471" @default.
• W2127403785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15505446" @default.
• W2127403785 hasPublicationYear "2004" @default.
• W2127403785 type Work @default.
• W2127403785 sameAs 2127403785 @default.
• W2127403785 citedByCount "90" @default.
• W2127403785 countsByYear W21274037852012 @default.
• W2127403785 countsByYear W21274037852013 @default.
• W2127403785 countsByYear W21274037852014 @default.
• W2127403785 countsByYear W21274037852015 @default.
• W2127403785 countsByYear W21274037852016 @default.
• W2127403785 countsByYear W21274037852017 @default.
• W2127403785 countsByYear W21274037852018 @default.
• W2127403785 countsByYear W21274037852019 @default.
• W2127403785 countsByYear W21274037852021 @default.
• W2127403785 countsByYear W21274037852022 @default.
• W2127403785 crossrefType "journal-article" @default.
• W2127403785 hasAuthorship W2127403785A5018403068 @default.
• W2127403785 hasAuthorship W2127403785A5042996287 @default.
• W2127403785 hasAuthorship W2127403785A5064307261 @default.
• W2127403785 hasAuthorship W2127403785A5076462126 @default.
• W2127403785 hasAuthorship W2127403785A5084632357 @default.
• W2127403785 hasBestOaLocation W21274037851 @default.
• W2127403785 hasConcept C111113717 @default.
• W2127403785 hasConcept C112705442 @default.
• W2127403785 hasConcept C2776239304 @default.
• W2127403785 hasConcept C2776277131 @default.
• W2127403785 hasConcept C2776814716 @default.
• W2127403785 hasConcept C2778891214 @default.
• W2127403785 hasConcept C2781097354 @default.
• W2127403785 hasConcept C2908647359 @default.
• W2127403785 hasConcept C3019240266 @default.
• W2127403785 hasConcept C3020079912 @default.
• W2127403785 hasConcept C42219234 @default.
• W2127403785 hasConcept C71924100 @default.
• W2127403785 hasConcept C98274493 @default.
• W2127403785 hasConcept C99454951 @default.
• W2127403785 hasConceptScore W2127403785C111113717 @default.
• W2127403785 hasConceptScore W2127403785C112705442 @default.
• W2127403785 hasConceptScore W2127403785C2776239304 @default.
• W2127403785 hasConceptScore W2127403785C2776277131 @default.
• W2127403785 hasConceptScore W2127403785C2776814716 @default.
• W2127403785 hasConceptScore W2127403785C2778891214 @default.
• W2127403785 hasConceptScore W2127403785C2781097354 @default.
• W2127403785 hasConceptScore W2127403785C2908647359 @default.
• W2127403785 hasConceptScore W2127403785C3019240266 @default.
• W2127403785 hasConceptScore W2127403785C3020079912 @default.
• W2127403785 hasConceptScore W2127403785C42219234 @default.
• W2127403785 hasConceptScore W2127403785C71924100 @default.
• W2127403785 hasConceptScore W2127403785C98274493 @default.
• W2127403785 hasConceptScore W2127403785C99454951 @default.
• W2127403785 hasIssue "5" @default.
• W2127403785 hasLocation W21274037851 @default.
• W2127403785 hasLocation W21274037852 @default.
• W2127403785 hasLocation W21274037853 @default.
• W2127403785 hasLocation W21274037854 @default.

• next