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• W2127439083 abstract "Purpose : To determine the ability of radiation to modulate kidney tubule epithelial cell expression of various molecules involved in regulating extracellular matrix accumulation (collagen types I and III, fibronectin, plasminogen activator-inhibitor 1 (PAI-1), TGF-beta and tissue inhibitor of metalloproteinases-2 (TIMP-2)) and degradation (plasminogen activators u-PA or t-PA, MMP-2 and MMP-9). Materials and methods : NRK52E rat tubule epithelial cells were placed in serum-free medium 24h prior to irradiation with single doses of 1.0-10.0 Gy 137 Cs gamma-rays. After irradiation, cells were maintained in serum-free medium for up to 48h. Results : Irradiation of NRK52E cells was associated with significant dose-dependent increases in collagen I (p <0.05) and PAI-1 (p 0.002) mRNA. Collagen III mRNA levels also exhibited a dose-dependent increase; however, this increase failed to reach levels that were statistically significant. Fibronectin mRNA levels were unaltered following irradiation. Radiation also led to an isoform-specific alteration in TGF-beta expression; TGF-beta1 mRNA increased, TGF-beta3 mRNA decreased. The amount of TGF-beta protein secreted into the medium was unchanged following irradiation; however, there was a fivefold increase in the relative amount of active TGF-beta. Irradiation was also associated with differential changes in MMP expression: active MMP-2 levels increased, while MMP-9 levels were unaltered; PA secretion into the medium was unchanged following irradiation. Conclusions : Irradiation of rat kidney tubule epithelial cells leads to altered production of various molecules associated with extracellular matrix accumulation and degradation." @default.
• W2127439083 created "2016-06-24" @default.
• W2127439083 creator A5047662839 @default.
• W2127439083 date "2000-01-01" @default.
• W2127439083 modified "2023-09-30" @default.
• W2127439083 title "Irradiation of rat tubule epithelial cells alters the expression of gene products associated with the synthesis and degradation of extracellular matrix" @default.
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• W2127439083 doi "https://doi.org/10.1080/095530000138736" @default.
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