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• W2127462085 startingPage "10959" @default.
• W2127462085 abstract "The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusions has created new concerns about the iatrogenic spread of transmissible spongiform encephalopathies (TSEs)/prion diseases through blood and plasma-derived products and has increased the need to develop efficient methods for detection of the agent in biologics. Here, we report the first successful generation of spleen-derived murine stromal cell cultures that persistently propagate two mouse-adapted isolates of human TSE agents, mouse-adapted vCJD, and Fukuoka 1. These new cell cultures can be used efficiently for studies of the pathogenesis of the disease, for development of diagnostics and therapeutics, and as a rapid ex vivo assay for TSE inactivation/removal procedures." @default.
• W2127462085 created "2016-06-24" @default.
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• W2127462085 date "2008-11-01" @default.
• W2127462085 modified "2023-10-02" @default.
• W2127462085 title "Persistent Propagation of Variant Creutzfeldt-Jakob Disease Agent in Murine Spleen Stromal Cell Culture with Features of Mesenchymal Stem Cells" @default.
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• W2127462085 doi "https://doi.org/10.1128/jvi.01085-08" @default.
• W2127462085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2573195" @default.
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• W2127462085 hasPublicationYear "2008" @default.
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