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- W2127480169 abstract "Experiments were carried out to examine the major histocompatibility complex (MHC) restriction of an antibody-specific immunoregulatory function that develops following conventional immunization with hapten-carrier conjugates. It was found that carrier-primed hosts reconstituted with Ly-2.2+ T cells from hapten-carrier-immunized donors were able to suppress adoptively transferred primary B cells. The effective suppression of primary B cell responses was dependent on syngeny between the suppressing T cell population and the target B cells at both MHC and Igh. These findings indicate that T cells that function through the recognition of B cell antibody are restricted in their function by gene products of the MHC, similar to the restrictions observed for the recognition of conventional antigens." @default.
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- W2127480169 date "1982-01-01" @default.
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- W2127480169 title "Antibody-specific immunoregulation is restricted by the major histocompatibility gene complex" @default.
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- W2127480169 doi "https://doi.org/10.1002/eji.1830121114" @default.
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