FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127484231> ?p ?o ?g. }

• W2127484231 endingPage "1075" @default.
• W2127484231 startingPage "1068" @default.
• W2127484231 abstract "The pituitary-expressed GH1 gene was screened for mutation in a group of 74 children with familial short stature. Two novel mutations were identified: an Ile179Met substitution and a -360A-->G promoter variant. The Ile179Met variant was shown to exhibit a similar degree of resistance to proteolysis as wild-type GH, indicating that the introduction of Met does not cause significant misfolding. Secretion of Ile179Met GH from rat pituitary cells was also similar to that of wild type. Although receptor binding studies failed to show any difference in binding characteristics, molecular modeling studies suggested that the Ile179Met substitution might nevertheless perturb interactions between GH and the GH receptor loop containing the hotspot residue Trp169, thereby affecting signal transduction. The ability of the Ile179Met variant to activate a signal transducer and activator of transcription (STAT) 5-responsive luciferase reporter gene and induce phosphorylation of STAT 5 and ERK was therefore studied. In contrast to its ability to activate STAT 5 normally, activation of ERK by the Ile179Met variant was reduced to half that observed with wild type. Although differential effects on the activation of distinct signaling pathways by a mutant receptor agonist are unprecedented, these findings also suggest that the ERK pathway could play a role in mediating the action of GH." @default.
• W2127484231 created "2016-06-24" @default.
• W2127484231 creator A5000866423 @default.
• W2127484231 creator A5008355893 @default.
• W2127484231 creator A5014417228 @default.
• W2127484231 creator A5018472642 @default.
• W2127484231 creator A5024650264 @default.
• W2127484231 creator A5029336912 @default.
• W2127484231 creator A5035030872 @default.
• W2127484231 creator A5040903807 @default.
• W2127484231 creator A5040953880 @default.
• W2127484231 creator A5042443600 @default.
• W2127484231 creator A5056497987 @default.
• W2127484231 creator A5068658241 @default.
• W2127484231 creator A5073602997 @default.
• W2127484231 creator A5082590730 @default.
• W2127484231 creator A5086703911 @default.
• W2127484231 creator A5088092370 @default.
• W2127484231 creator A5088379932 @default.
• W2127484231 creator A5091015345 @default.
• W2127484231 date "2004-03-01" @default.
• W2127484231 modified "2023-10-11" @default.
• W2127484231 title "A Novel Dysfunctional Growth Hormone Variant (Ile179Met) Exhibits a Decreased Ability to Activate the Extracellular Signal-Regulated Kinase Pathway" @default.
• W2127484231 cites W1579739997 @default.
• W2127484231 cites W1908808369 @default.
• W2127484231 cites W1964052811 @default.
• W2127484231 cites W1978208333 @default.
• W2127484231 cites W1980353405 @default.
• W2127484231 cites W1984828633 @default.
• W2127484231 cites W1985922043 @default.
• W2127484231 cites W1991543649 @default.
• W2127484231 cites W1992265701 @default.
• W2127484231 cites W2001230322 @default.
• W2127484231 cites W2004942022 @default.
• W2127484231 cites W2012711566 @default.
• W2127484231 cites W2016337945 @default.
• W2127484231 cites W2025206161 @default.
• W2127484231 cites W2025864476 @default.
• W2127484231 cites W2029958719 @default.
• W2127484231 cites W2037226702 @default.
• W2127484231 cites W2038910312 @default.
• W2127484231 cites W2042655455 @default.
• W2127484231 cites W2058527555 @default.
• W2127484231 cites W2061144747 @default.
• W2127484231 cites W2062138583 @default.
• W2127484231 cites W2062358030 @default.
• W2127484231 cites W2067495770 @default.
• W2127484231 cites W2071878606 @default.
• W2127484231 cites W2073030003 @default.
• W2127484231 cites W2075454057 @default.
• W2127484231 cites W2076848886 @default.
• W2127484231 cites W2085344822 @default.
• W2127484231 cites W2107796077 @default.
• W2127484231 cites W2119816993 @default.
• W2127484231 cites W2129485552 @default.
• W2127484231 cites W2135812210 @default.
• W2127484231 cites W2144665452 @default.
• W2127484231 doi "https://doi.org/10.1210/jc.2003-030652" @default.
• W2127484231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15001589" @default.
• W2127484231 hasPublicationYear "2004" @default.
• W2127484231 type Work @default.
• W2127484231 sameAs 2127484231 @default.
• W2127484231 citedByCount "46" @default.
• W2127484231 countsByYear W21274842312013 @default.
• W2127484231 countsByYear W21274842312014 @default.
• W2127484231 countsByYear W21274842312015 @default.
• W2127484231 countsByYear W21274842312016 @default.
• W2127484231 countsByYear W21274842312021 @default.
• W2127484231 countsByYear W21274842312022 @default.
• W2127484231 countsByYear W21274842312023 @default.
• W2127484231 crossrefType "journal-article" @default.
• W2127484231 hasAuthorship W2127484231A5000866423 @default.
• W2127484231 hasAuthorship W2127484231A5008355893 @default.
• W2127484231 hasAuthorship W2127484231A5014417228 @default.
• W2127484231 hasAuthorship W2127484231A5018472642 @default.
• W2127484231 hasAuthorship W2127484231A5024650264 @default.
• W2127484231 hasAuthorship W2127484231A5029336912 @default.
• W2127484231 hasAuthorship W2127484231A5035030872 @default.
• W2127484231 hasAuthorship W2127484231A5040903807 @default.
• W2127484231 hasAuthorship W2127484231A5040953880 @default.
• W2127484231 hasAuthorship W2127484231A5042443600 @default.
• W2127484231 hasAuthorship W2127484231A5056497987 @default.
• W2127484231 hasAuthorship W2127484231A5068658241 @default.
• W2127484231 hasAuthorship W2127484231A5073602997 @default.
• W2127484231 hasAuthorship W2127484231A5082590730 @default.
• W2127484231 hasAuthorship W2127484231A5086703911 @default.
• W2127484231 hasAuthorship W2127484231A5088092370 @default.
• W2127484231 hasAuthorship W2127484231A5088379932 @default.
• W2127484231 hasAuthorship W2127484231A5091015345 @default.
• W2127484231 hasBestOaLocation W21274842311 @default.
• W2127484231 hasConcept C104317684 @default.
• W2127484231 hasConcept C11960822 @default.
• W2127484231 hasConcept C126037660 @default.
• W2127484231 hasConcept C126322002 @default.
• W2127484231 hasConcept C134018914 @default.
• W2127484231 hasConcept C143065580 @default.
• W2127484231 hasConcept C170493617 @default.
• W2127484231 hasConcept C171958077 @default.

• next