Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127485764> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2127485764 abstract "The management of patients with severe refractory asthma (SRA) is a difficult task that may benefit from the use of non-invasive assessment by biomarkers. Interleukin (IL)-13 is a cytokine with a central role in the TH2 response. The object of this study was the assessment of IL-13 as a biomarker of asthma control in patients with SRA. We recruited 170 patients (47 with SRA) from two University asthma clinics. Patients were submitted to pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), and sputum induction with calculation of inflammatory cells and measurement of IL-13 in the supernatant. Asthma control test (ACT) was used for evaluation of asthma control (ACT values >19 identified well-controlled asthma). Severe refractory asthma was defined by the ATS criteria. IL-13 in sputum supernatant was increased in patients with SRA compared to patients with mild-to-moderate asthma [median (IQR): 156 (80-245) pg/mL vs. 78 (66-103) pg/mL, p<0.001], as well as in patients with persistent airflow obstruction [99 (71-199) pg/mL vs. 80 (66-105) pg/mL, p=0.0081]. IL-13 presented good diagnostic accuracy for the detection of not-well-controlled asthma in the whole group [specificity 94.2%, sensitivity 80.6% for a cut-off point of ≤ 156 pg/mL; area under the curve (AUC) 0.920]. The diagnostic accuracy of IL-13 was superior to FeNO or sputum eosinophils in patients with SRA (AUC 0.981 vs. 0.688 vs. 0.645 respectively; p<0.001). IL-13 in induced sputum may represent a useful index of disease control in patients with SRA. The better diagnostic accuracy of IL-13, compared to FeNO and sputum eosinophils, indicates a central role of this mediator in SRA." @default.
- W2127485764 created "2016-06-24" @default.
- W2127485764 creator A5001926067 @default.
- W2127485764 creator A5010301737 @default.
- W2127485764 creator A5029339474 @default.
- W2127485764 creator A5031123659 @default.
- W2127485764 creator A5039311118 @default.
- W2127485764 creator A5046774961 @default.
- W2127485764 creator A5057623122 @default.
- W2127485764 creator A5064085023 @default.
- W2127485764 creator A5076353213 @default.
- W2127485764 date "2015-03-23" @default.
- W2127485764 modified "2023-09-24" @default.
- W2127485764 title "Sputum interleukin (IL)‐13 as a biomarker for the evaluation of asthma control" @default.
- W2127485764 doi "https://doi.org/10.1186/2045-7022-5-s2-o9" @default.
- W2127485764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4407166" @default.
- W2127485764 hasPublicationYear "2015" @default.
- W2127485764 type Work @default.
- W2127485764 sameAs 2127485764 @default.
- W2127485764 citedByCount "1" @default.
- W2127485764 countsByYear W21274857642017 @default.
- W2127485764 crossrefType "journal-article" @default.
- W2127485764 hasAuthorship W2127485764A5001926067 @default.
- W2127485764 hasAuthorship W2127485764A5010301737 @default.
- W2127485764 hasAuthorship W2127485764A5029339474 @default.
- W2127485764 hasAuthorship W2127485764A5031123659 @default.
- W2127485764 hasAuthorship W2127485764A5039311118 @default.
- W2127485764 hasAuthorship W2127485764A5046774961 @default.
- W2127485764 hasAuthorship W2127485764A5057623122 @default.
- W2127485764 hasAuthorship W2127485764A5064085023 @default.
- W2127485764 hasAuthorship W2127485764A5076353213 @default.
- W2127485764 hasBestOaLocation W21274857641 @default.
- W2127485764 hasConcept C126322002 @default.
- W2127485764 hasConcept C142724271 @default.
- W2127485764 hasConcept C185592680 @default.
- W2127485764 hasConcept C203014093 @default.
- W2127485764 hasConcept C2776042228 @default.
- W2127485764 hasConcept C2776301714 @default.
- W2127485764 hasConcept C2780333948 @default.
- W2127485764 hasConcept C2781069245 @default.
- W2127485764 hasConcept C2781142857 @default.
- W2127485764 hasConcept C2781197716 @default.
- W2127485764 hasConcept C55493867 @default.
- W2127485764 hasConcept C58471807 @default.
- W2127485764 hasConcept C71924100 @default.
- W2127485764 hasConcept C76318530 @default.
- W2127485764 hasConcept C90924648 @default.
- W2127485764 hasConceptScore W2127485764C126322002 @default.
- W2127485764 hasConceptScore W2127485764C142724271 @default.
- W2127485764 hasConceptScore W2127485764C185592680 @default.
- W2127485764 hasConceptScore W2127485764C203014093 @default.
- W2127485764 hasConceptScore W2127485764C2776042228 @default.
- W2127485764 hasConceptScore W2127485764C2776301714 @default.
- W2127485764 hasConceptScore W2127485764C2780333948 @default.
- W2127485764 hasConceptScore W2127485764C2781069245 @default.
- W2127485764 hasConceptScore W2127485764C2781142857 @default.
- W2127485764 hasConceptScore W2127485764C2781197716 @default.
- W2127485764 hasConceptScore W2127485764C55493867 @default.
- W2127485764 hasConceptScore W2127485764C58471807 @default.
- W2127485764 hasConceptScore W2127485764C71924100 @default.
- W2127485764 hasConceptScore W2127485764C76318530 @default.
- W2127485764 hasConceptScore W2127485764C90924648 @default.
- W2127485764 hasIssue "S2" @default.
- W2127485764 hasLocation W21274857641 @default.
- W2127485764 hasLocation W21274857642 @default.
- W2127485764 hasLocation W21274857643 @default.
- W2127485764 hasOpenAccess W2127485764 @default.
- W2127485764 hasPrimaryLocation W21274857641 @default.
- W2127485764 hasRelatedWork W2099861526 @default.
- W2127485764 hasRelatedWork W2122443163 @default.
- W2127485764 hasRelatedWork W2122721529 @default.
- W2127485764 hasRelatedWork W2122808695 @default.
- W2127485764 hasRelatedWork W2172048551 @default.
- W2127485764 hasRelatedWork W2790972126 @default.
- W2127485764 hasRelatedWork W3031160509 @default.
- W2127485764 hasRelatedWork W3160616359 @default.
- W2127485764 hasRelatedWork W4221034048 @default.
- W2127485764 hasRelatedWork W4366215731 @default.
- W2127485764 hasVolume "5" @default.
- W2127485764 isParatext "false" @default.
- W2127485764 isRetracted "false" @default.
- W2127485764 magId "2127485764" @default.
- W2127485764 workType "article" @default.