FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127487303> ?p ?o ?g. }

• W2127487303 endingPage "e31" @default.
• W2127487303 startingPage "e31" @default.
• W2127487303 abstract "Metabolic processes studied by PET are quantified traditionally using compartmental models, which relate the time course of the tracer concentration in tissue to that in arterial blood. For liver studies, the use of arterial input may, however, cause systematic errors to the estimated kinetic parameters, because of ignorance of the dual blood supply from the hepatic artery and the portal vein to the liver. <b>Methods:</b> Six pigs underwent PET after [¹⁵O]carbon monoxide inhalation, 3-<i>O</i>-[¹¹C]methylglucose (MG) injection, and [¹⁸F]FDG injection. For the glucose scans, PET data were acquired for 90 min. Hepatic arterial and portal venous blood samples and flows were measured during the scan. The dual-input function was calculated as the flow-weighted input. <b>Results:</b> For both MG and FDG, the compartmental analysis using arterial input led to systematic underestimation of the rate constants for rapid blood–tissue exchange. Furthermore, the arterial input led to absurdly low estimates for the extracellular volume compared with the independently measured hepatic blood volume of 0.25 ± 0.01 mL/mL (milliliter blood per milliliter liver tissue). In contrast, the use of a dual-input function provided parameter estimates that were in agreement with liver physiology. Using the dual-input function, the clearances into the liver cells (K₁ = 1.11 ± 0.11 mL/min/mL for MG; K₁ = 1.07 ± 0.19 mL/min/mL for FDG) were comparable with the liver blood flow (F = 1.02 ± 0.05 mL/min/mL). As required physiologically, the extracellular volumes estimated using the dual-input function were larger than the hepatic blood volume. The linear Gjedde–Patlak analysis produced parameter estimates that were unaffected by the choice of input function, because this analysis was confined to time scales for which the arterial-input and dual-input functions were very similar. <b>Conclusion:</b> Compartmental analysis of MG and FDG kinetics using dynamic PET data requires measurements of dual-input activity concentrations. Using the dual-input function, physiologically reasonable parameter estimates of K₁, k₂, and V_p were obtained, whereas the use of conventional arterial sampling underestimated these parameters compared with independent measurements of hepatic flow and hepatic blood volume. In contrast, the linear Gjedde–Patlak analysis, being less informative but more robust, gave similar parameter estimates (K, V) with both input functions." @default.
• W2127487303 created "2016-06-24" @default.
• W2127487303 creator A5069979151 @default.
• W2127487303 date "2013-08-29" @default.
• W2127487303 modified "2023-10-11" @default.
• W2127487303 title "Evidence in support of the validity of the TNF brake hypothesis" @default.
• W2127487303 cites W2032718492 @default.
• W2127487303 cites W2054215607 @default.
• W2127487303 cites W2068354144 @default.
• W2127487303 cites W2091640487 @default.
• W2127487303 cites W2123235923 @default.
• W2127487303 cites W2143071958 @default.
• W2127487303 cites W2149713883 @default.
• W2127487303 cites W2158734690 @default.
• W2127487303 doi "https://doi.org/10.1136/annrheumdis-2013-204485" @default.
• W2127487303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23989987" @default.
• W2127487303 hasPublicationYear "2013" @default.
• W2127487303 type Work @default.
• W2127487303 sameAs 2127487303 @default.
• W2127487303 citedByCount "7" @default.
• W2127487303 countsByYear W21274873032014 @default.
• W2127487303 countsByYear W21274873032015 @default.
• W2127487303 countsByYear W21274873032016 @default.
• W2127487303 countsByYear W21274873032018 @default.
• W2127487303 countsByYear W21274873032023 @default.
• W2127487303 crossrefType "journal-article" @default.
• W2127487303 hasAuthorship W2127487303A5069979151 @default.
• W2127487303 hasConcept C126322002 @default.
• W2127487303 hasConcept C176674119 @default.
• W2127487303 hasConcept C2776820930 @default.
• W2127487303 hasConcept C2776954882 @default.
• W2127487303 hasConcept C2779537118 @default.
• W2127487303 hasConcept C2989005 @default.
• W2127487303 hasConcept C2992208098 @default.
• W2127487303 hasConcept C37557685 @default.
• W2127487303 hasConcept C42219234 @default.
• W2127487303 hasConcept C71924100 @default.
• W2127487303 hasConceptScore W2127487303C126322002 @default.
• W2127487303 hasConceptScore W2127487303C176674119 @default.
• W2127487303 hasConceptScore W2127487303C2776820930 @default.
• W2127487303 hasConceptScore W2127487303C2776954882 @default.
• W2127487303 hasConceptScore W2127487303C2779537118 @default.
• W2127487303 hasConceptScore W2127487303C2989005 @default.
• W2127487303 hasConceptScore W2127487303C2992208098 @default.
• W2127487303 hasConceptScore W2127487303C37557685 @default.
• W2127487303 hasConceptScore W2127487303C42219234 @default.
• W2127487303 hasConceptScore W2127487303C71924100 @default.
• W2127487303 hasIssue "12" @default.
• W2127487303 hasLocation W21274873031 @default.
• W2127487303 hasLocation W21274873032 @default.
• W2127487303 hasOpenAccess W2127487303 @default.
• W2127487303 hasPrimaryLocation W21274873031 @default.
• W2127487303 hasRelatedWork W1571844492 @default.
• W2127487303 hasRelatedWork W1608248014 @default.
• W2127487303 hasRelatedWork W1965325679 @default.
• W2127487303 hasRelatedWork W2005973474 @default.
• W2127487303 hasRelatedWork W2048802470 @default.
• W2127487303 hasRelatedWork W2054241747 @default.
• W2127487303 hasRelatedWork W2084734332 @default.
• W2127487303 hasRelatedWork W2090259619 @default.
• W2127487303 hasRelatedWork W2356860550 @default.
• W2127487303 hasRelatedWork W2392407047 @default.
• W2127487303 hasVolume "72" @default.
• W2127487303 isParatext "false" @default.
• W2127487303 isRetracted "false" @default.
• W2127487303 magId "2127487303" @default.
• W2127487303 workType "article" @default.