FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127487757> ?p ?o ?g. }

• W2127487757 endingPage "816" @default.
• W2127487757 startingPage "807" @default.
• W2127487757 abstract "Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates blood glucose level post-prandially. It has been proposed that GLP-1 can be used in type 2 diabetes (T2D) mellitus treatment because of its insulinotropic action. Despite its remarkable advantages, GLP-1 suffers the disadvantage of an extremely short half-life owing to its degradation by the dipeptidyl peptidase IV protease. One way of overcoming this drawback is GLP-1 gene delivery. Here we show effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes (TNCs) in Zucker diabetic fatty (ZDF) animal model of T2D. The expression plasmid fused the GLP-1 gene to a Furin cleavage site was driven by a cytomegalovirus promoter/enhancer. TNCs were prepared by mixing this plasmid with chitosans of specific molecular weight (MW), degree of deacetylation (DDA) and ratio of chitosan amine to DNA phosphate (N:P ratio). Animals injected with the TNC chitosan 92-10-5 (DDA-MW-N:P) showed GLP-1 plasma levels of about fivefold higher than that in non-treated animals and the insulinotropic effect of recombinant GLP-1 was shown by a threefold increase in plasma insulin concentration when compared with untreated animals. Intraperitoneal glucose tolerance tests revealed an efficacious decrease of blood glucose compared with controls for up to 24 days after treatment, where injections of this formulation allowed near-normalization of blood glucose level. TNCs composed of specific chitosans and GLP-1-expressing plasmid constructs showed an impressive ability to harness the profound therapeutic potential of GLP-1 for the treatment of T2D mellitus." @default.
• W2127487757 created "2016-06-24" @default.
• W2127487757 creator A5001132085 @default.
• W2127487757 creator A5030751859 @default.
• W2127487757 creator A5058699706 @default.
• W2127487757 creator A5071107934 @default.
• W2127487757 date "2011-03-17" @default.
• W2127487757 modified "2023-10-01" @default.
• W2127487757 title "Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes" @default.
• W2127487757 cites W1507814807 @default.
• W2127487757 cites W1578843331 @default.
• W2127487757 cites W1885047062 @default.
• W2127487757 cites W1964212912 @default.
• W2127487757 cites W1966006931 @default.
• W2127487757 cites W1966048813 @default.
• W2127487757 cites W1969932276 @default.
• W2127487757 cites W1972903573 @default.
• W2127487757 cites W1973842058 @default.
• W2127487757 cites W1979228623 @default.
• W2127487757 cites W1984740259 @default.
• W2127487757 cites W1994743271 @default.
• W2127487757 cites W2000465889 @default.
• W2127487757 cites W2000511325 @default.
• W2127487757 cites W2007757049 @default.
• W2127487757 cites W2008411184 @default.
• W2127487757 cites W2008460460 @default.
• W2127487757 cites W2008691798 @default.
• W2127487757 cites W2009287324 @default.
• W2127487757 cites W2010208232 @default.
• W2127487757 cites W2013082477 @default.
• W2127487757 cites W2016193795 @default.
• W2127487757 cites W2025313266 @default.
• W2127487757 cites W2027385673 @default.
• W2127487757 cites W2031185644 @default.
• W2127487757 cites W2036167841 @default.
• W2127487757 cites W2044313895 @default.
• W2127487757 cites W2044410325 @default.
• W2127487757 cites W2044453064 @default.
• W2127487757 cites W2047708866 @default.
• W2127487757 cites W2053944183 @default.
• W2127487757 cites W2054164089 @default.
• W2127487757 cites W2054884070 @default.
• W2127487757 cites W2071798899 @default.
• W2127487757 cites W2080128749 @default.
• W2127487757 cites W2081072375 @default.
• W2127487757 cites W2081392051 @default.
• W2127487757 cites W2082070432 @default.
• W2127487757 cites W2082857033 @default.
• W2127487757 cites W2087707716 @default.
• W2127487757 cites W2096444181 @default.
• W2127487757 cites W2096880961 @default.
• W2127487757 cites W2099166156 @default.
• W2127487757 cites W2104753509 @default.
• W2127487757 cites W2106824929 @default.
• W2127487757 cites W2118889627 @default.
• W2127487757 cites W2124182221 @default.
• W2127487757 cites W2129322435 @default.
• W2127487757 cites W2131619373 @default.
• W2127487757 cites W2139470224 @default.
• W2127487757 cites W2143014102 @default.
• W2127487757 cites W2143069126 @default.
• W2127487757 cites W2150137315 @default.
• W2127487757 cites W2156316935 @default.
• W2127487757 cites W2158035912 @default.
• W2127487757 cites W2167454178 @default.
• W2127487757 cites W2172204314 @default.
• W2127487757 cites W223168254 @default.
• W2127487757 cites W2327640792 @default.
• W2127487757 cites W4234825176 @default.
• W2127487757 cites W1979610088 @default.
• W2127487757 doi "https://doi.org/10.1038/gt.2011.25" @default.
• W2127487757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21412280" @default.
• W2127487757 hasPublicationYear "2011" @default.
• W2127487757 type Work @default.
• W2127487757 sameAs 2127487757 @default.
• W2127487757 citedByCount "45" @default.
• W2127487757 countsByYear W21274877572012 @default.
• W2127487757 countsByYear W21274877572013 @default.
• W2127487757 countsByYear W21274877572014 @default.
• W2127487757 countsByYear W21274877572015 @default.
• W2127487757 countsByYear W21274877572016 @default.
• W2127487757 countsByYear W21274877572017 @default.
• W2127487757 countsByYear W21274877572019 @default.
• W2127487757 countsByYear W21274877572020 @default.
• W2127487757 countsByYear W21274877572021 @default.
• W2127487757 countsByYear W21274877572022 @default.
• W2127487757 countsByYear W21274877572023 @default.
• W2127487757 crossrefType "journal-article" @default.
• W2127487757 hasAuthorship W2127487757A5001132085 @default.
• W2127487757 hasAuthorship W2127487757A5030751859 @default.
• W2127487757 hasAuthorship W2127487757A5058699706 @default.
• W2127487757 hasAuthorship W2127487757A5071107934 @default.
• W2127487757 hasBestOaLocation W21274877571 @default.
• W2127487757 hasConcept C104317684 @default.
• W2127487757 hasConcept C111599444 @default.
• W2127487757 hasConcept C111936080 @default.
• W2127487757 hasConcept C134018914 @default.
• W2127487757 hasConcept C135983454 @default.

• next