Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127524103> ?p ?o ?g. }
- W2127524103 abstract "Large conductance, Ca(2+)-activated K(+) (BK) channels represent an important pathway for the outward flux of K(+) ions from the intracellular compartment in response to membrane depolarization, and/or an elevation in cytosolic free [Ca(2+)]. They are functionally expressed in a range of mammalian tissues (e.g., nerve and smooth muscles), where they can either enhance or dampen membrane excitability. The diversity of BK channel activity results from the considerable alternative mRNA splicing and post-translational modification (e.g., phosphorylation) of key domains within the pore-forming α subunit of the channel complex. Most of these modifications are regulated by distinct upstream cell signaling pathways that influence the structure and/or gating properties of the holo-channel and ultimately, cellular function. The channel complex may also contain auxiliary subunits that further affect channel gating and behavior, often in a tissue-specific manner. Recent studies in human and animal models have provided strong evidence that abnormal BK channel expression/function contributes to a range of pathologies in nerve and smooth muscle. By targeting the upstream regulatory events modulating BK channel behavior, it may be possible to therapeutically intervene and alter BK channel expression/function in a beneficial manner." @default.
- W2127524103 created "2016-06-24" @default.
- W2127524103 creator A5001932915 @default.
- W2127524103 creator A5026724439 @default.
- W2127524103 date "2014-08-22" @default.
- W2127524103 modified "2023-09-23" @default.
- W2127524103 title "The regulation of BK channel activity by pre- and post-translational modifications" @default.
- W2127524103 cites W1482585622 @default.
- W2127524103 cites W1493953490 @default.
- W2127524103 cites W1496926742 @default.
- W2127524103 cites W1550564549 @default.
- W2127524103 cites W1595865504 @default.
- W2127524103 cites W1602374960 @default.
- W2127524103 cites W1604744466 @default.
- W2127524103 cites W1667367966 @default.
- W2127524103 cites W1701982621 @default.
- W2127524103 cites W1883087802 @default.
- W2127524103 cites W1900274922 @default.
- W2127524103 cites W1954118366 @default.
- W2127524103 cites W1964080030 @default.
- W2127524103 cites W1965052647 @default.
- W2127524103 cites W1969042720 @default.
- W2127524103 cites W1980069683 @default.
- W2127524103 cites W1980805930 @default.
- W2127524103 cites W1981397708 @default.
- W2127524103 cites W1982320423 @default.
- W2127524103 cites W1982518334 @default.
- W2127524103 cites W1986172439 @default.
- W2127524103 cites W1987785656 @default.
- W2127524103 cites W1990141054 @default.
- W2127524103 cites W1990262394 @default.
- W2127524103 cites W1991624086 @default.
- W2127524103 cites W1991890788 @default.
- W2127524103 cites W1992260558 @default.
- W2127524103 cites W1992550839 @default.
- W2127524103 cites W1995336089 @default.
- W2127524103 cites W1995405544 @default.
- W2127524103 cites W1996457989 @default.
- W2127524103 cites W1999601435 @default.
- W2127524103 cites W2000499608 @default.
- W2127524103 cites W2003716397 @default.
- W2127524103 cites W2004800687 @default.
- W2127524103 cites W2006353836 @default.
- W2127524103 cites W2006423698 @default.
- W2127524103 cites W2006985572 @default.
- W2127524103 cites W2007860569 @default.
- W2127524103 cites W2008093120 @default.
- W2127524103 cites W2014303314 @default.
- W2127524103 cites W2014968048 @default.
- W2127524103 cites W2016763372 @default.
- W2127524103 cites W2017301720 @default.
- W2127524103 cites W2022831345 @default.
- W2127524103 cites W2030205108 @default.
- W2127524103 cites W2032812775 @default.
- W2127524103 cites W2037588355 @default.
- W2127524103 cites W2038621068 @default.
- W2127524103 cites W2039106149 @default.
- W2127524103 cites W2042006175 @default.
- W2127524103 cites W2042178804 @default.
- W2127524103 cites W2043827733 @default.
- W2127524103 cites W2048644561 @default.
- W2127524103 cites W2048797514 @default.
- W2127524103 cites W2050256938 @default.
- W2127524103 cites W2050296008 @default.
- W2127524103 cites W2051023125 @default.
- W2127524103 cites W2054546745 @default.
- W2127524103 cites W2061545526 @default.
- W2127524103 cites W2062220778 @default.
- W2127524103 cites W2063845237 @default.
- W2127524103 cites W2064205875 @default.
- W2127524103 cites W2065528657 @default.
- W2127524103 cites W2066363179 @default.
- W2127524103 cites W2066411558 @default.
- W2127524103 cites W2068244727 @default.
- W2127524103 cites W2068847639 @default.
- W2127524103 cites W2069111106 @default.
- W2127524103 cites W2076425088 @default.
- W2127524103 cites W2082871219 @default.
- W2127524103 cites W2082985051 @default.
- W2127524103 cites W2083664471 @default.
- W2127524103 cites W2084230206 @default.
- W2127524103 cites W2085113848 @default.
- W2127524103 cites W2085548554 @default.
- W2127524103 cites W2089157424 @default.
- W2127524103 cites W2090033907 @default.
- W2127524103 cites W2091352000 @default.
- W2127524103 cites W2093090047 @default.
- W2127524103 cites W2095278806 @default.
- W2127524103 cites W2096167103 @default.
- W2127524103 cites W2098581642 @default.
- W2127524103 cites W2100081225 @default.
- W2127524103 cites W2102178988 @default.
- W2127524103 cites W2110188816 @default.
- W2127524103 cites W2112696231 @default.
- W2127524103 cites W2112827709 @default.
- W2127524103 cites W2114385744 @default.
- W2127524103 cites W2114838789 @default.
- W2127524103 cites W2115513800 @default.
- W2127524103 cites W2115676911 @default.
- W2127524103 cites W2115993532 @default.