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• W2127549063 abstract "Human endogenous retrovirus (HERV)-specific T cell responses in HIV-1-infected adults have been reported. Whether HERV-specific immunity exists in vertically HIV-1-infected children is unknown. We performed a cross-sectional analysis of HERV-specific T cell responses in 42 vertically HIV-1-infected children. HERV (-H, -K, and -L family)-specific T cell responses were identified in 26 of 42 subjects, with the greatest magnitude observed for the responses to HERV-L. These HERV-specific T cell responses were inversely correlated with the HIV-1 plasma viral load and positively correlated with CD4(+) T cell counts. These data indicate that HERV-specific T cells may participate in controlling HIV-1 replication and that certain highly conserved HERV-derived proteins may serve as promising therapeutic vaccine targets in HIV-1-infected children." @default.
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• W2127549063 date "2011-11-01" @default.
• W2127549063 modified "2023-09-23" @default.
• W2127549063 title "Identification of Human Endogenous Retrovirus-Specific T Cell Responses in Vertically HIV-1-Infected Subjects" @default.
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• W2127549063 doi "https://doi.org/10.1128/jvi.05418-11" @default.
• W2127549063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3194955" @default.
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