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• W2127568004 abstract "The maintenance of ion channel homeostasis, or channelostasis, is a complex puzzle in neurons with extensive dendritic arborization, encompassing a combinatorial diversity of proteins that encode these channels and their auxiliary subunits, their localization profiles, and associated signaling machinery. Despite this, neurons exhibit amazingly stereotypic, topographically continuous maps of several functional properties along their active dendritic arbor. Here, we asked whether the membrane composition of neurons, at the level of individual ion channels, is constrained by this structural requirement of sustaining several functional maps along the same topograph. We performed global sensitivity analysis on morphologically realistic conductance-based models of hippocampal pyramidal neurons that coexpressed six well-characterized functional maps along their trunk. We generated randomized models by varying 32 underlying parameters and constrained these models with quantitative experimental measurements from the soma and dendrites of hippocampal pyramidal neurons. Analyzing valid models that satisfied experimental constraints on all six functional maps, we found topographically analogous functional maps to emerge from disparate model parameters with weak pairwise correlations between parameters. Finally, we derived a methodology to assess the contribution of individual channel conductances to the various functional measurements, using virtual knockout simulations on the valid model population. We found that the virtual knockout of individual channels resulted in variable, measurement- and location-specific impacts across the population. Our results suggest collective channelostasis as a mechanism behind the robust emergence of analogous functional maps and have significant ramifications for the localization and targeting of ion channels and enzymes that regulate neural coding and homeostasis." @default.
• W2127568004 created "2016-06-24" @default.
• W2127568004 creator A5025878194 @default.
• W2127568004 creator A5084158132 @default.
• W2127568004 date "2014-04-07" @default.
• W2127568004 modified "2023-10-16" @default.
• W2127568004 title "Homeostasis of functional maps in active dendrites emerges in the absence of individual channelostasis" @default.
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• W2127568004 doi "https://doi.org/10.1073/pnas.1316599111" @default.
• W2127568004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4035944" @default.
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