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- W2127581896 abstract "### Patient:A 44-year-old, African-American female with sickle cell disease (SCD) presented for evaluation of pulmonary hypertension.### Past Medical History:Sickle cell disease, pulmonary hypertension, hepatitis C (genotype 2), iron overload secondary to transfusion, hypothyroidism, and human leukocyte antigen (HLA)-alloimmunization due to multiple blood product transfusions for a simple transfusion every 3 weeks.### Past Immunohematology History:Patient’s RBCs phenotyped as group A, Rh positive, C-E+c+e+, K:-1, Fy(a−b−), Jk(a+b−), and S-s+. Red blood units transfused were ABO-compatible and negative for C and K antigens as per hospital policy to transfuse Rh- and K-matched RBC to patients with SCD. One month later, anti-Swain-Langley (Sla) was identified (Figure 1). This antibody is considered clinically insignificant and reactivity was observed when testing with polyethylene glycol (PEG) and low ionic-strength saline (LISS) showed <1+ reactivity with all cells tested except for the Sla antigen negative red cell. Sla is an antigen in the Knops blood group system and is destroyed by 0.2 M dithiothreitol (DTT). This technique was used, and the chemically-treated cells were used to rule out additional antibodies. Care must be taken when performing rule outs using 0.2 M DTT-treated cells because antigens other than Sla are destroyed. Antigens usually denatured or altered include Yta, JMH, Knops, LW, Kell, Lutheran, Dombrock, and Cromer blood group antigens.1 The patient remained on C and K antigen negative restrictions and received units that were crossmatch-incompatible due to the anti-Sla. Approximately 3 years later, an antibody screen was performed (Figure 2), and anti-S was suspected. Additional testing confirmed the new antibody. After the identification of anti-S the patient was restricted to receive phenotypically-matched (ABO/Rh-compatible, C, K1, Fya, Jkb, and S negative) RBC units. It was decided not to give units negative for the Fyb antigen since it is common …" @default.
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- W2127581896 date "2010-05-01" @default.
- W2127581896 modified "2023-10-17" @default.
- W2127581896 title "The Importance of Antibody Detection and Identification in the Chronically Transfused Patient" @default.
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- W2127581896 doi "https://doi.org/10.1309/lm4zqd8j8hhenonv" @default.
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