FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127590525> ?p ?o ?g. }

• W2127590525 endingPage "1324" @default.
• W2127590525 startingPage "1313" @default.
• W2127590525 abstract "The POMC gene is transcribed in 5–10% of adult rat anterior pituitary cells and nearly all intermediate lobe cells, but the end product peptide hormones produced by these two cell populations are distinct. We have here used in situ hybridization with 3HPOMC cRNA probes to investigate the temporal and spatial distribution of POMC mRNA containing cells during development of both lobes of the adenohypophysis. These hybridization patterns were, in addition, compared to the immunocytochemical distribution of POMC-related peptides on the same or adjacent sections. In both POMC populations, POMC-mRNA detection preceded POMC-derived peptide accumulation by at least 0.5 days. POMCmRNA was first detected in the ventral aspect of Rathke's pouch (which will give rise to the anterior lobe) at e13, which was two days earlier than POMC transcripts were first detected in the intermediate lobe; this result provides strong evidence that factors eliciting POMC transcription in these two populations act at distinct times during development. Further, since POMC mRNA containing cells were restricted to the anterior lobe during stages when intermediate lobe-like POMC peptides have been characterized biochemically, these results confirm immunocytochemical results and demonstrate that developmentally regulated alterations in the extent of POMC posttranslational processing occur during prenatal differentiation of anterior lobe POMC cells. POMC expression in the intermediate lobe was first observed in the midcaudal region in the midsagittal plane and subsequently extended in a gradient-like pattern to the rest of the intermediate lobe. Finally, semiquantitation of in situ hybridization signals documented that increases in the relative levels of POMC mRNA/cell occur at specific ages in both anterior and intermediate lobe POMC cell populations and demonstrated that adult POMC mRNA/cell levels are not achieved before birth in either the anterior or intermediate lobe POMC cell populations." @default.
• W2127590525 created "2016-06-24" @default.
• W2127590525 creator A5057526897 @default.
• W2127590525 creator A5073262602 @default.
• W2127590525 creator A5082192432 @default.
• W2127590525 date "1989-08-01" @default.
• W2127590525 modified "2023-09-23" @default.
• W2127590525 title "Analysis of Proopiomelanocortin Gene Expression during Prenatal Development of the Rat Pituitary Gland" @default.
• W2127590525 cites W1496979921 @default.
• W2127590525 cites W1508518209 @default.
• W2127590525 cites W1592298255 @default.
• W2127590525 cites W1631661863 @default.
• W2127590525 cites W1821237662 @default.
• W2127590525 cites W1971089519 @default.
• W2127590525 cites W1973519871 @default.
• W2127590525 cites W1975307541 @default.
• W2127590525 cites W1979573787 @default.
• W2127590525 cites W1987793678 @default.
• W2127590525 cites W1993481530 @default.
• W2127590525 cites W2000372395 @default.
• W2127590525 cites W2008711880 @default.
• W2127590525 cites W2020439478 @default.
• W2127590525 cites W2022328614 @default.
• W2127590525 cites W2029763858 @default.
• W2127590525 cites W2031785770 @default.
• W2127590525 cites W2032352955 @default.
• W2127590525 cites W2038961537 @default.
• W2127590525 cites W2039939928 @default.
• W2127590525 cites W2045490270 @default.
• W2127590525 cites W2046823123 @default.
• W2127590525 cites W2064109349 @default.
• W2127590525 cites W2070586655 @default.
• W2127590525 cites W2074260855 @default.
• W2127590525 cites W2078714906 @default.
• W2127590525 cites W2079743165 @default.
• W2127590525 cites W2088357731 @default.
• W2127590525 cites W2095228325 @default.
• W2127590525 cites W2111344548 @default.
• W2127590525 cites W2115430692 @default.
• W2127590525 cites W2120417507 @default.
• W2127590525 cites W2135074372 @default.
• W2127590525 cites W2141433061 @default.
• W2127590525 cites W2144634347 @default.
• W2127590525 cites W2158905256 @default.
• W2127590525 cites W2174758426 @default.
• W2127590525 cites W2465025882 @default.
• W2127590525 cites W2884159172 @default.
• W2127590525 cites W2081264545 @default.
• W2127590525 doi "https://doi.org/10.1210/mend-3-8-1313" @default.
• W2127590525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2528692" @default.
• W2127590525 hasPublicationYear "1989" @default.
• W2127590525 type Work @default.
• W2127590525 sameAs 2127590525 @default.
• W2127590525 citedByCount "57" @default.
• W2127590525 countsByYear W21275905252014 @default.
• W2127590525 countsByYear W21275905252016 @default.
• W2127590525 crossrefType "journal-article" @default.
• W2127590525 hasAuthorship W2127590525A5057526897 @default.
• W2127590525 hasAuthorship W2127590525A5073262602 @default.
• W2127590525 hasAuthorship W2127590525A5082192432 @default.
• W2127590525 hasBestOaLocation W21275905251 @default.
• W2127590525 hasConcept C104317684 @default.
• W2127590525 hasConcept C105580179 @default.
• W2127590525 hasConcept C105702510 @default.
• W2127590525 hasConcept C126322002 @default.
• W2127590525 hasConcept C134018914 @default.
• W2127590525 hasConcept C150194340 @default.
• W2127590525 hasConcept C153911025 @default.
• W2127590525 hasConcept C2777003273 @default.
• W2127590525 hasConcept C2777658017 @default.
• W2127590525 hasConcept C2777876421 @default.
• W2127590525 hasConcept C2779029589 @default.
• W2127590525 hasConcept C2780017199 @default.
• W2127590525 hasConcept C2780090379 @default.
• W2127590525 hasConcept C2781309135 @default.
• W2127590525 hasConcept C35866371 @default.
• W2127590525 hasConcept C54355233 @default.
• W2127590525 hasConcept C71315377 @default.
• W2127590525 hasConcept C71924100 @default.
• W2127590525 hasConcept C79381400 @default.
• W2127590525 hasConcept C81439078 @default.
• W2127590525 hasConcept C86803240 @default.
• W2127590525 hasConceptScore W2127590525C104317684 @default.
• W2127590525 hasConceptScore W2127590525C105580179 @default.
• W2127590525 hasConceptScore W2127590525C105702510 @default.
• W2127590525 hasConceptScore W2127590525C126322002 @default.
• W2127590525 hasConceptScore W2127590525C134018914 @default.
• W2127590525 hasConceptScore W2127590525C150194340 @default.
• W2127590525 hasConceptScore W2127590525C153911025 @default.
• W2127590525 hasConceptScore W2127590525C2777003273 @default.
• W2127590525 hasConceptScore W2127590525C2777658017 @default.
• W2127590525 hasConceptScore W2127590525C2777876421 @default.
• W2127590525 hasConceptScore W2127590525C2779029589 @default.
• W2127590525 hasConceptScore W2127590525C2780017199 @default.
• W2127590525 hasConceptScore W2127590525C2780090379 @default.
• W2127590525 hasConceptScore W2127590525C2781309135 @default.
• W2127590525 hasConceptScore W2127590525C35866371 @default.
• W2127590525 hasConceptScore W2127590525C54355233 @default.

• next