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- W2127595954 endingPage "120" @default.
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- W2127595954 abstract "Resistance to cell death induction has been recognized as a hallmark of cancer. Increasing understanding of the underlying molecular events regulating different cell death mechanisms like apoptosis, endoplasmic reticulum stress, autophagy, necroptosis and others has opened new possibilities for targeted interference with these pathways. While conventional chemotherapeutic agents usually inhibit cell cycle progression, DNA replication or mitosis execution, novel agents like small molecule kinase inhibitors also target survival-related kinases and signaling pathways and contribute to overcome resistance to chemotherapy and apoptosis. Additionally, antibodies targeting cellular death receptors have been described to specifically target tumor cells only. This review briefly highlights the pathways involved in (apoptotic) cell death and summarizes the current state of development of specific modulators of cell death and how they can help to improve the tolerability of chemotherapy regimens and increase survival rates in patients with advanced cancer diseases." @default.
- W2127595954 created "2016-06-24" @default.
- W2127595954 creator A5004904788 @default.
- W2127595954 creator A5018588889 @default.
- W2127595954 date "2012-01-01" @default.
- W2127595954 modified "2023-10-17" @default.
- W2127595954 title "Apoptosis-Modulating Drugs for Improved Cancer Therapy" @default.
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