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- W2127598660 abstract "In high-throughput screening (HTS), compounds can be tested in mixtures using the orthogonal pooling strategy. However, several experimental studies that used two-way orthogonal pooling have shown that the rate of false negative testing errors is still not negligible. Because replicate screening is prohibited due to the large number of compounds that need to be tested, the false negative results eventually lead to loss of active compounds. This article generalizes the two-way orthogonal pooling strategy to a three-way pooling and develops statistical methods to evaluate the false negative rate (FNR) and the false positive rate (FPR) for the two-way and three-way pooling strategies. Calculations show that the three-way pooling strategy decreases the FNR but increases the FPR to approximately three times that of the two-way pooling strategy. In terms of strategy selection, three-way pooling requires 50% more tests than two-way pooling but gains benefit when the testing technique has low sensitivity and high..." @default.
- W2127598660 created "2016-06-24" @default.
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- W2127598660 date "2015-07-03" @default.
- W2127598660 modified "2023-10-05" @default.
- W2127598660 title "Statistical Evaluation of the Orthogonal Pooling Strategy for High-Throughput Screening" @default.
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- W2127598660 doi "https://doi.org/10.1080/19466315.2015.1043394" @default.
- W2127598660 hasPublicationYear "2015" @default.
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