FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127607575> ?p ?o ?g. }

• W2127607575 endingPage "1000" @default.
• W2127607575 startingPage "993" @default.
• W2127607575 abstract "Abstract In congestive heart failure (CHF), endogenous compounds with ouabainlike activity (OLA) may contribute to the maintenance of the circulatory homeostasis by peripheral as well as central effects. In the present study, we assessed changes in peripheral (plasma and left ventricle) and central (pituitary, hypothalamus, pons, and cortex) OLA in two animal models of CHF and determined whether brain OLA mediates sympathetic hyperactivity in CHF. Cardiomyopathic hamsters with their controls were studied at 9 months of age for tissue OLA. Rats were studied 4 weeks after acute coronary artery ligation for tissue OLA and sympathetic activity. In both models, left ventricular end-diastolic pressure was markedly increased. CHF was associated with significant increases in both plasma and tissue OLA in both models. In the brain, the most marked (twofold to threefold) increases occurred in the hypothalamus. In vitro, all OLA measured could be blocked by antibody Fab fragments (Digibind). Conscious rats with CHF showed elevated plasma catecholamines and enhanced responses of mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) to air stress and to intracerebroventricular (ICV) injection of the α 2 -adrenergic receptor agonist guanabenz compared with sham-operated rats. ICV administration of the Fab fragments did not change resting RSNA or responses to air stress at 1 hour. However, 18 hours after injection of the Fab fragments, resting RSNA levels had significantly decreased compared with the control values, and plasma catecholamine levels had decreased to control values. Moreover, the magnitudes of the increases or decreases in MAP, HR, and RSNA to air stress or ICV guanabenz had markedly decreased as well and were now similar to those observed in sham-operated control animals. The present results show that the development of CHF in two animal models is associated with marked increases in both peripheral and brain OLA. Brain OLA appears to mediate the increase in resting sympathetic tone and enhanced sympathoexcitatory responses to stress." @default.
• W2127607575 created "2016-06-24" @default.
• W2127607575 creator A5002739810 @default.
• W2127607575 creator A5013474083 @default.
• W2127607575 creator A5017613139 @default.
• W2127607575 creator A5036807087 @default.
• W2127607575 date "1995-11-01" @default.
• W2127607575 modified "2023-09-24" @default.
• W2127607575 title "Brain ‘Ouabain’ Mediates Sympathetic Hyperactivity in Congestive Heart Failure" @default.
• W2127607575 cites W1684853394 @default.
• W2127607575 cites W1836031771 @default.
• W2127607575 cites W1952889644 @default.
• W2127607575 cites W1965203336 @default.
• W2127607575 cites W1966809056 @default.
• W2127607575 cites W1966907188 @default.
• W2127607575 cites W1977648865 @default.
• W2127607575 cites W1984193593 @default.
• W2127607575 cites W1984687894 @default.
• W2127607575 cites W2013021063 @default.
• W2127607575 cites W2014697620 @default.
• W2127607575 cites W2015364594 @default.
• W2127607575 cites W2032436700 @default.
• W2127607575 cites W2033201173 @default.
• W2127607575 cites W2036745719 @default.
• W2127607575 cites W2066971334 @default.
• W2127607575 cites W2088901422 @default.
• W2127607575 cites W2091167579 @default.
• W2127607575 cites W2113520583 @default.
• W2127607575 cites W2116503493 @default.
• W2127607575 cites W2127646569 @default.
• W2127607575 cites W2137625635 @default.
• W2127607575 cites W2208430048 @default.
• W2127607575 cites W2278174033 @default.
• W2127607575 cites W2336104014 @default.
• W2127607575 cites W2399986635 @default.
• W2127607575 cites W2409865561 @default.
• W2127607575 cites W2414041256 @default.
• W2127607575 cites W4255093947 @default.
• W2127607575 doi "https://doi.org/10.1161/01.res.77.5.993" @default.
• W2127607575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7554154" @default.
• W2127607575 hasPublicationYear "1995" @default.
• W2127607575 type Work @default.
• W2127607575 sameAs 2127607575 @default.
• W2127607575 citedByCount "77" @default.
• W2127607575 countsByYear W21276075752012 @default.
• W2127607575 countsByYear W21276075752013 @default.
• W2127607575 countsByYear W21276075752014 @default.
• W2127607575 countsByYear W21276075752015 @default.
• W2127607575 countsByYear W21276075752016 @default.
• W2127607575 countsByYear W21276075752017 @default.
• W2127607575 countsByYear W21276075752018 @default.
• W2127607575 countsByYear W21276075752019 @default.
• W2127607575 countsByYear W21276075752022 @default.
• W2127607575 crossrefType "journal-article" @default.
• W2127607575 hasAuthorship W2127607575A5002739810 @default.
• W2127607575 hasAuthorship W2127607575A5013474083 @default.
• W2127607575 hasAuthorship W2127607575A5017613139 @default.
• W2127607575 hasAuthorship W2127607575A5036807087 @default.
• W2127607575 hasConcept C126322002 @default.
• W2127607575 hasConcept C134018914 @default.
• W2127607575 hasConcept C170493617 @default.
• W2127607575 hasConcept C2775894120 @default.
• W2127607575 hasConcept C2777003273 @default.
• W2127607575 hasConcept C2777953023 @default.
• W2127607575 hasConcept C2778198053 @default.
• W2127607575 hasConcept C2778921608 @default.
• W2127607575 hasConcept C2778938600 @default.
• W2127607575 hasConcept C71924100 @default.
• W2127607575 hasConcept C84393581 @default.
• W2127607575 hasConceptScore W2127607575C126322002 @default.
• W2127607575 hasConceptScore W2127607575C134018914 @default.
• W2127607575 hasConceptScore W2127607575C170493617 @default.
• W2127607575 hasConceptScore W2127607575C2775894120 @default.
• W2127607575 hasConceptScore W2127607575C2777003273 @default.
• W2127607575 hasConceptScore W2127607575C2777953023 @default.
• W2127607575 hasConceptScore W2127607575C2778198053 @default.
• W2127607575 hasConceptScore W2127607575C2778921608 @default.
• W2127607575 hasConceptScore W2127607575C2778938600 @default.
• W2127607575 hasConceptScore W2127607575C71924100 @default.
• W2127607575 hasConceptScore W2127607575C84393581 @default.
• W2127607575 hasIssue "5" @default.
• W2127607575 hasLocation W21276075751 @default.
• W2127607575 hasLocation W21276075752 @default.
• W2127607575 hasOpenAccess W2127607575 @default.
• W2127607575 hasPrimaryLocation W21276075751 @default.
• W2127607575 hasRelatedWork W1966437072 @default.
• W2127607575 hasRelatedWork W1978175539 @default.
• W2127607575 hasRelatedWork W1981630754 @default.
• W2127607575 hasRelatedWork W1986276964 @default.
• W2127607575 hasRelatedWork W2035465482 @default.
• W2127607575 hasRelatedWork W2053421360 @default.
• W2127607575 hasRelatedWork W2068749436 @default.
• W2127607575 hasRelatedWork W2114343773 @default.
• W2127607575 hasRelatedWork W2169102024 @default.
• W2127607575 hasRelatedWork W2172131010 @default.
• W2127607575 hasVolume "77" @default.
• W2127607575 isParatext "false" @default.
• W2127607575 isRetracted "false" @default.

• next