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• W2127616923 abstract "Mesothelioma is a rare but very aggressive tumor derived from mesothelial cells. A number of often complex but nonrandom cytogenetic abnormalities have been found in these tumors, resulting in loss of chromosome bands 14q32 and 22q12 in more than 35% of the cases. In this study, we used RNA sequencing to search for fusion transcripts in a mesothelioma carrying a t(14;22)(q32;q12) as the sole chromosomal aberration and found an EWSR1–YY1 and its reciprocal YY1–EWSR1 fusion transcript. Screening 15 additional cases of mesothelioma from which we had RNA but no cytogenetic information, we identified one more tumor carrying an EWSR1–YY1 fusion gene but not the reciprocal YY1–EWSR1 transcript. RT‐polymerase chain reaction and sequencing showed that in both cases exon 8 of EWSR1 (nucleotide 1,139, accession number NM_013986 version 3, former exon 7 in sequence with accession number X66899) was fused to exon 2 of YY1 (nucleotide 1,160, accession number NM_003403 version 3). The EWSR1 breakpoint in exon 8 in the EWSR1–YY1 chimeric transcript is similar to what is found in other fusions involving EWSR1 such as EWSR1–FLI1 , EWSR1–DDIT3 , and EWSR1–ATF1 . The EWSR1–YY1‐encoded protein is an abnormal transcription factor with the transactivation domain of EWSR1 and the DNA‐binding domain of YY1. This is the first study to detect a specific fusion gene in mesothelioma (the reason how frequent the EWSR1–YY1 fusion is remains uncertain) and also the first time that direct involvement of YY1 in oncogenesis has been demonstrated. © 2013 Wiley Periodicals, Inc." @default.
• W2127616923 created "2016-06-24" @default.
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• W2127616923 date "2013-04-30" @default.
• W2127616923 modified "2023-10-16" @default.
• W2127616923 title "RNA sequencing identifies fusion of the<i>EWSR1</i>and<i>YY1</i>genes in mesothelioma with t(14;22)(q32;q12)" @default.
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• W2127616923 doi "https://doi.org/10.1002/gcc.22068" @default.
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