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• W2127641390 abstract "IL-13 is a Th2 cytokine that promotes alternative activation (M2 polarization) in primary human monocytes. Our studies have characterized the functional IL-13 receptor complex and the downstream signaling events in response to IL-13 stimulation in alternatively activated monocytes/macrophages. In this report, we present evidence that IL-13 induces the activation of a Src family tyrosine kinase, which is required for IL-13 induction of M2 gene expression, including 15-lipoxygenase (15-LO). Our data show that Src kinase activity regulates IL-13-induced p38 MAPK tyrosine phosphorylation via the upstream kinases MKK3 or MKK6. Our findings also reveal that the IL-13 receptor-associated tyrosine kinase Jak2 is required for the activation of both Src kinase as well as p38 MAPK. Further, we found that Src tyrosine kinase-mediated activation of p38 MAPK is required for Stat1 and Stat3 serine 727 phosphorylation in alternatively activated monocytes/macrophages. Additional studies identify Hck as the specific Src family member, stimulated by IL-13 and involved in regulating both p38 MAPK activation and p38 MAPK-mediated 15-LO expression. Finally we show that the Hck regulates the expression of other alternative state (M2)-specific genes (Mannose receptor, MAO-A, and CD36) and therefore conclude that Hck acts as a key regulator controlling gene expression in alternatively activated monocytes/macrophages." @default.
• W2127641390 created "2016-06-24" @default.
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• W2127641390 creator A5035859687 @default.
• W2127641390 date "2011-10-01" @default.
• W2127641390 modified "2023-09-27" @default.
• W2127641390 title "Hck Is a Key Regulator of Gene Expression in Alternatively Activated Human Monocytes" @default.
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• W2127641390 doi "https://doi.org/10.1074/jbc.m111.291492" @default.
• W2127641390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3196116" @default.
• W2127641390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21878628" @default.
• W2127641390 hasPublicationYear "2011" @default.
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