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- W2127647563 abstract "Dopaminergic innervation of the entorhinal cortex may contribute to the integration and encoding of sensory information. The primary olfactory cortex (piriform cortex) projects to the superficial layers of the entorhinal cortex, and converging dopaminergic inputs from the ventral tegmental area may modulate processes in the entorhinal cortex related to the salience of olfactory stimuli. In the current study, food-restricted rats were trained to dig in cups filled with scented sand and to discriminate between two different odours to obtain a buried food-reward which was always associated with one odour (CS+). Upon reaching criterion performance on this task, animals underwent sham surgery or 6-hydroxydopamine lesions of the entorhinal cortex. After retraining on the original discrimination rule, olfactory sensitivity was tested using cups containing decreasing amounts of the original CS+ odour. Animals showed graded decrements in response accuracy as the concentration of odorant was reduced, but no significant differences were observed between control and lesioned animals. In addition, lesioned animals did not differ in their ability to learn to perform the discrimination task with a new odour pair at low concentrations, and did not show differences in their ability to respond accurately to either the initial or novel odour pair after a delay of two weeks. These findings show that scented sand can be used as an effective stimulus to assess the sensitivity to olfactory stimuli in the rat, but do not provide evidence for deficits in olfactory sensitivity or memory performance in animals with 6-OHDA lesions of the entorhinal cortex." @default.
- W2127647563 created "2016-06-24" @default.
- W2127647563 creator A5035680420 @default.
- W2127647563 date "2010-05-02" @default.
- W2127647563 modified "2023-09-27" @default.
- W2127647563 title "Testing the role of dopamine in olfactory sensitivity and learning in the entorhinal cortex" @default.
- W2127647563 cites W12280647 @default.
- W2127647563 cites W1498040700 @default.
- W2127647563 cites W1562438742 @default.
- W2127647563 cites W1566413981 @default.
- W2127647563 cites W1659384861 @default.
- W2127647563 cites W1799486297 @default.
- W2127647563 cites W1929312129 @default.
- W2127647563 cites W1946764292 @default.
- W2127647563 cites W1964004822 @default.
- W2127647563 cites W1964227543 @default.
- W2127647563 cites W1967132785 @default.
- W2127647563 cites W1969455604 @default.
- W2127647563 cites W1970792572 @default.
- W2127647563 cites W1970822140 @default.
- W2127647563 cites W1972178738 @default.
- W2127647563 cites W1973371295 @default.
- W2127647563 cites W1975898250 @default.
- W2127647563 cites W1978796138 @default.
- W2127647563 cites W1979466796 @default.
- W2127647563 cites W1981381216 @default.
- W2127647563 cites W1981414216 @default.
- W2127647563 cites W1982096257 @default.
- W2127647563 cites W1987555292 @default.
- W2127647563 cites W1987572299 @default.
- W2127647563 cites W1990287391 @default.
- W2127647563 cites W1991559147 @default.
- W2127647563 cites W1994046709 @default.
- W2127647563 cites W1994192521 @default.
- W2127647563 cites W1994343347 @default.
- W2127647563 cites W1998033984 @default.
- W2127647563 cites W1998152406 @default.
- W2127647563 cites W1998996300 @default.
- W2127647563 cites W1999077789 @default.
- W2127647563 cites W2003352068 @default.
- W2127647563 cites W2004752114 @default.
- W2127647563 cites W2005890257 @default.
- W2127647563 cites W2008657099 @default.
- W2127647563 cites W2013588344 @default.
- W2127647563 cites W2016270477 @default.
- W2127647563 cites W2017053258 @default.
- W2127647563 cites W2018196751 @default.
- W2127647563 cites W2018947767 @default.
- W2127647563 cites W2019044369 @default.
- W2127647563 cites W2023699349 @default.
- W2127647563 cites W2023924009 @default.
- W2127647563 cites W2025040353 @default.
- W2127647563 cites W2027274005 @default.
- W2127647563 cites W2029759341 @default.
- W2127647563 cites W2034285129 @default.
- W2127647563 cites W2036682063 @default.
- W2127647563 cites W2042720451 @default.
- W2127647563 cites W2042756251 @default.
- W2127647563 cites W204690133 @default.
- W2127647563 cites W2049842417 @default.
- W2127647563 cites W2052546085 @default.
- W2127647563 cites W2052842784 @default.
- W2127647563 cites W2057470835 @default.
- W2127647563 cites W2058292925 @default.
- W2127647563 cites W2059141480 @default.
- W2127647563 cites W2060761472 @default.
- W2127647563 cites W2061697038 @default.
- W2127647563 cites W2062281705 @default.
- W2127647563 cites W2063113281 @default.
- W2127647563 cites W2064409479 @default.
- W2127647563 cites W2065718678 @default.
- W2127647563 cites W2066552807 @default.
- W2127647563 cites W2066864925 @default.
- W2127647563 cites W2068134369 @default.
- W2127647563 cites W2068949066 @default.
- W2127647563 cites W2069899696 @default.
- W2127647563 cites W2072998406 @default.
- W2127647563 cites W2076425653 @default.
- W2127647563 cites W2080112291 @default.
- W2127647563 cites W2080874911 @default.
- W2127647563 cites W2081882516 @default.
- W2127647563 cites W2082501635 @default.
- W2127647563 cites W2084005333 @default.
- W2127647563 cites W2086084364 @default.
- W2127647563 cites W2086935208 @default.
- W2127647563 cites W2090915949 @default.
- W2127647563 cites W2093362207 @default.
- W2127647563 cites W2093438640 @default.
- W2127647563 cites W2096536196 @default.
- W2127647563 cites W2101895134 @default.
- W2127647563 cites W2102112708 @default.
- W2127647563 cites W2105888718 @default.
- W2127647563 cites W2107711062 @default.
- W2127647563 cites W2108310775 @default.
- W2127647563 cites W2112660211 @default.
- W2127647563 cites W2118363612 @default.
- W2127647563 cites W2126387724 @default.
- W2127647563 cites W2127829387 @default.
- W2127647563 cites W2129789527 @default.
- W2127647563 cites W2130303084 @default.