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- W2127654037 abstract "The immune system has evolved a variety of mechanisms to achieve and maintain tolerance both centrally and in the periphery. Central tolerance is achieved through negative selection of autoreactive T cells, while peripheral tolerance is achieved primarily via three mechanisms: activation-induced cell death, anergy, and the induction of regulatory T cells. Three forms of these regulatory T cells have been described: those that function via the production of the cytokine IL-10 (T regulatory 1 cells), transforming growth factor beta (Th3 cells), and a population of T cells that suppresses proliferation via a cell-contact-dependent mechanism (CD4+CD25+ TR cells). The present review focuses on the third form of peripheral tolerance - the induction of regulatory T cells. The review will address the induction of the three types of regulatory T cells, the mechanisms by which they suppress T-cell responses in the periphery, the role they play in immune homeostasis, and the potential these cells have as therapeutic agents in immune-mediated disease." @default.
- W2127654037 created "2016-06-24" @default.
- W2127654037 creator A5019862484 @default.
- W2127654037 creator A5050390918 @default.
- W2127654037 date "2004-01-01" @default.
- W2127654037 modified "2023-10-16" @default.
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- W2127654037 doi "https://doi.org/10.1186/ar1226" @default.
- W2127654037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/546291" @default.
- W2127654037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15380036" @default.
- W2127654037 hasPublicationYear "2004" @default.
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