Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127658533> ?p ?o ?g. }
- W2127658533 endingPage "679" @default.
- W2127658533 startingPage "670" @default.
- W2127658533 abstract "Application of array comparative genomic hybridization (aCGH) has allowed an unprecedented high-resolution analysis of cancer genomes. We developed a custom genome-wide oligonucleotide microarray interrogating 493 genes involved in hematological disorders. We analyzed 55 patients with hematological neoplasms by using this microarray. In 33 patients with apparent normal conventional cytogenetic analysis, aneuploidy or isochromosomes were detected in 12% (4 of 33) of the patients by aCGH. The chromosomal changes included trisomy of chromosomes 10, 14, and 15, tetrasomy 11, and isochromosome 17q. In 17 patients with chronic lymphocytic leukemia who were initially investigated by using a panel of standard fluorescence in situ hybridization probes, additional copy number changes that were not interrogated by the fluorescence in situ hybridization (FISH) panel were detected in 47% (8 of 17) of the patients by aCGH. Important copy number changes included gain on 2p16 involving REL and BCL11A genes, rearrangements of chromosomes 8 and 15, and trisomy of chromosomes 19 and 22. In five patients with known abnormal karyotypes, aCGH identified the origin of two marker chromosomes and detected microdeletions at five breakpoints involved in three apparent balanced translocations. Our results suggest that a subset of potentially significant genomic alterations is missed by the currently available cytogenetic techniques. This pilot study clearly demonstrates high sensitivity of oligonucleotide aCGH for potential use in diagnosis and follow-up in patients with hematological neoplasms." @default.
- W2127658533 created "2016-06-24" @default.
- W2127658533 creator A5006247268 @default.
- W2127658533 creator A5017449569 @default.
- W2127658533 creator A5041368187 @default.
- W2127658533 creator A5042496388 @default.
- W2127658533 creator A5052883326 @default.
- W2127658533 creator A5061084392 @default.
- W2127658533 creator A5071790804 @default.
- W2127658533 creator A5072387201 @default.
- W2127658533 creator A5085310926 @default.
- W2127658533 creator A5089918245 @default.
- W2127658533 creator A5090317029 @default.
- W2127658533 date "2010-09-01" @default.
- W2127658533 modified "2023-09-27" @default.
- W2127658533 title "Array Comparative Genomic Hybridization Detects Chromosomal Abnormalities in Hematological Cancers That Are Not Detected by Conventional Cytogenetics" @default.
- W2127658533 cites W1559197668 @default.
- W2127658533 cites W1966472517 @default.
- W2127658533 cites W1967513959 @default.
- W2127658533 cites W1968127793 @default.
- W2127658533 cites W1977525386 @default.
- W2127658533 cites W1977620605 @default.
- W2127658533 cites W1978406461 @default.
- W2127658533 cites W1981784854 @default.
- W2127658533 cites W1988383700 @default.
- W2127658533 cites W1996100423 @default.
- W2127658533 cites W2006486191 @default.
- W2127658533 cites W2012863300 @default.
- W2127658533 cites W2013141132 @default.
- W2127658533 cites W2025037523 @default.
- W2127658533 cites W2026631621 @default.
- W2127658533 cites W2027210182 @default.
- W2127658533 cites W2030403715 @default.
- W2127658533 cites W2034979835 @default.
- W2127658533 cites W2035117018 @default.
- W2127658533 cites W2037202528 @default.
- W2127658533 cites W2039356250 @default.
- W2127658533 cites W2042524059 @default.
- W2127658533 cites W2045952235 @default.
- W2127658533 cites W2050027087 @default.
- W2127658533 cites W2056113180 @default.
- W2127658533 cites W2058595408 @default.
- W2127658533 cites W2062056015 @default.
- W2127658533 cites W2063936314 @default.
- W2127658533 cites W2068385770 @default.
- W2127658533 cites W2075303273 @default.
- W2127658533 cites W2096643040 @default.
- W2127658533 cites W2097830047 @default.
- W2127658533 cites W2120951429 @default.
- W2127658533 cites W2123153650 @default.
- W2127658533 cites W2126788747 @default.
- W2127658533 cites W2127016965 @default.
- W2127658533 cites W2132306604 @default.
- W2127658533 cites W2133174470 @default.
- W2127658533 cites W2140100111 @default.
- W2127658533 cites W2140423522 @default.
- W2127658533 cites W2159140367 @default.
- W2127658533 cites W2161911433 @default.
- W2127658533 cites W2167045537 @default.
- W2127658533 doi "https://doi.org/10.2353/jmoldx.2010.090192" @default.
- W2127658533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2928432" @default.
- W2127658533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20724749" @default.
- W2127658533 hasPublicationYear "2010" @default.
- W2127658533 type Work @default.
- W2127658533 sameAs 2127658533 @default.
- W2127658533 citedByCount "25" @default.
- W2127658533 countsByYear W21276585332012 @default.
- W2127658533 countsByYear W21276585332013 @default.
- W2127658533 countsByYear W21276585332014 @default.
- W2127658533 countsByYear W21276585332015 @default.
- W2127658533 countsByYear W21276585332016 @default.
- W2127658533 countsByYear W21276585332017 @default.
- W2127658533 countsByYear W21276585332018 @default.
- W2127658533 countsByYear W21276585332019 @default.
- W2127658533 countsByYear W21276585332020 @default.
- W2127658533 countsByYear W21276585332022 @default.
- W2127658533 crossrefType "journal-article" @default.
- W2127658533 hasAuthorship W2127658533A5006247268 @default.
- W2127658533 hasAuthorship W2127658533A5017449569 @default.
- W2127658533 hasAuthorship W2127658533A5041368187 @default.
- W2127658533 hasAuthorship W2127658533A5042496388 @default.
- W2127658533 hasAuthorship W2127658533A5052883326 @default.
- W2127658533 hasAuthorship W2127658533A5061084392 @default.
- W2127658533 hasAuthorship W2127658533A5071790804 @default.
- W2127658533 hasAuthorship W2127658533A5072387201 @default.
- W2127658533 hasAuthorship W2127658533A5085310926 @default.
- W2127658533 hasAuthorship W2127658533A5089918245 @default.
- W2127658533 hasAuthorship W2127658533A5090317029 @default.
- W2127658533 hasBestOaLocation W21276585331 @default.
- W2127658533 hasConcept C104317684 @default.
- W2127658533 hasConcept C120821319 @default.
- W2127658533 hasConcept C124942203 @default.
- W2127658533 hasConcept C138626823 @default.
- W2127658533 hasConcept C141231307 @default.
- W2127658533 hasConcept C153911025 @default.
- W2127658533 hasConcept C174475383 @default.
- W2127658533 hasConcept C206936463 @default.
- W2127658533 hasConcept C2776229224 @default.