FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127705460> ?p ?o ?g. }

• W2127705460 endingPage "743" @default.
• W2127705460 startingPage "731" @default.
• W2127705460 abstract "Smallpox justifiably is feared because of its morbidity and mortality. Wide-spread population-level susceptibility to smallpox exists, and the only effective tool against the virus is a live, attenuated vaccine that is highly reactogenic and controversial. A significant minority of the population has contraindications that prevent preexposure use of this vaccine. Newer, safer, and equally immunogenic vaccines must be developed and licensed. Several live, attenuated vaccines are in clinical trials. Although these vaccines may prove to be less reactogenic, they still may not be administered safely to a significant portion of the population because they contain live, attenuated viruses. Newer vaccines will be needed if routine preexposure vaccination is to be instituted universally. The idea of a subunit or peptide-based vaccine is appealing, because it obviates potential safety concerns. It may be possible to use a more-attenuated, live vaccine strain for a large segment of the population on a preexposure basis and accept the morbidity and mortality that would result from its use on a postexposure basis, if necessary. The need for widespread population-level protection against variola infection is apparent. The use of the new biology tools to predict or define who might experience serious reactions to the smallpox vaccine and why these reactions occur is an area ripe for additional research. The reason why an individual develops postvaccinal encephalitis remains unknown, and the development is unpredictable and untreatable. In the future, if the mechanism behind such adverse events is defined, it may be possible to screen persons who are likely to experience such events. Although the authors remain proponents for use of the vaccine in alignment with the CDC vaccination program and recommendations, the previous concerns indicate that new knowledge must be gained and shared. Further research on attenuated vaccines and nonliving or peptide vaccines with equal efficacy should remain the goal, as it is apparent that smallpox vaccine once again will become part of the vaccinologist's and public health official's armamentarium in the decades to come." @default.
• W2127705460 created "2016-06-24" @default.
• W2127705460 creator A5057546038 @default.
• W2127705460 creator A5060316053 @default.
• W2127705460 date "2003-11-01" @default.
• W2127705460 modified "2023-10-06" @default.
• W2127705460 title "Smallpox vaccine: problems and prospects" @default.
• W2127705460 cites W1853800119 @default.
• W2127705460 cites W1966161268 @default.
• W2127705460 cites W1966817834 @default.
• W2127705460 cites W1993590571 @default.
• W2127705460 cites W2001856875 @default.
• W2127705460 cites W2005165325 @default.
• W2127705460 cites W2006017320 @default.
• W2127705460 cites W2006677975 @default.
• W2127705460 cites W2015609319 @default.
• W2127705460 cites W2023255264 @default.
• W2127705460 cites W2026230966 @default.
• W2127705460 cites W2038166412 @default.
• W2127705460 cites W2057371235 @default.
• W2127705460 cites W2065473088 @default.
• W2127705460 cites W2067594212 @default.
• W2127705460 cites W2071437607 @default.
• W2127705460 cites W2080556825 @default.
• W2127705460 cites W2081022718 @default.
• W2127705460 cites W2088152362 @default.
• W2127705460 cites W2089731941 @default.
• W2127705460 cites W2093746226 @default.
• W2127705460 cites W2098535963 @default.
• W2127705460 cites W2099460024 @default.
• W2127705460 cites W2110379511 @default.
• W2127705460 cites W2112414534 @default.
• W2127705460 cites W2112663219 @default.
• W2127705460 cites W2114852023 @default.
• W2127705460 cites W2116179982 @default.
• W2127705460 cites W2118488619 @default.
• W2127705460 cites W2127535867 @default.
• W2127705460 cites W2135382229 @default.
• W2127705460 cites W2167017098 @default.
• W2127705460 cites W2167207421 @default.
• W2127705460 cites W2168122647 @default.
• W2127705460 cites W2184646877 @default.
• W2127705460 cites W2340209280 @default.
• W2127705460 cites W2341708842 @default.
• W2127705460 doi "https://doi.org/10.1016/s0889-8561(03)00096-1" @default.
• W2127705460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14753389" @default.
• W2127705460 hasPublicationYear "2003" @default.
• W2127705460 type Work @default.
• W2127705460 sameAs 2127705460 @default.
• W2127705460 citedByCount "22" @default.
• W2127705460 countsByYear W21277054602013 @default.
• W2127705460 countsByYear W21277054602015 @default.
• W2127705460 countsByYear W21277054602018 @default.
• W2127705460 countsByYear W21277054602019 @default.
• W2127705460 countsByYear W21277054602022 @default.
• W2127705460 countsByYear W21277054602023 @default.
• W2127705460 crossrefType "journal-article" @default.
• W2127705460 hasAuthorship W2127705460A5057546038 @default.
• W2127705460 hasAuthorship W2127705460A5060316053 @default.
• W2127705460 hasConcept C104317684 @default.
• W2127705460 hasConcept C126322002 @default.
• W2127705460 hasConcept C142724271 @default.
• W2127705460 hasConcept C159047783 @default.
• W2127705460 hasConcept C177713679 @default.
• W2127705460 hasConcept C197934379 @default.
• W2127705460 hasConcept C203014093 @default.
• W2127705460 hasConcept C22070199 @default.
• W2127705460 hasConcept C2778417375 @default.
• W2127705460 hasConcept C2779272165 @default.
• W2127705460 hasConcept C2781356689 @default.
• W2127705460 hasConcept C2908647359 @default.
• W2127705460 hasConcept C40767141 @default.
• W2127705460 hasConcept C535046627 @default.
• W2127705460 hasConcept C54602769 @default.
• W2127705460 hasConcept C55493867 @default.
• W2127705460 hasConcept C60987743 @default.
• W2127705460 hasConcept C71924100 @default.
• W2127705460 hasConcept C86803240 @default.
• W2127705460 hasConcept C99454951 @default.
• W2127705460 hasConceptScore W2127705460C104317684 @default.
• W2127705460 hasConceptScore W2127705460C126322002 @default.
• W2127705460 hasConceptScore W2127705460C142724271 @default.
• W2127705460 hasConceptScore W2127705460C159047783 @default.
• W2127705460 hasConceptScore W2127705460C177713679 @default.
• W2127705460 hasConceptScore W2127705460C197934379 @default.
• W2127705460 hasConceptScore W2127705460C203014093 @default.
• W2127705460 hasConceptScore W2127705460C22070199 @default.
• W2127705460 hasConceptScore W2127705460C2778417375 @default.
• W2127705460 hasConceptScore W2127705460C2779272165 @default.
• W2127705460 hasConceptScore W2127705460C2781356689 @default.
• W2127705460 hasConceptScore W2127705460C2908647359 @default.
• W2127705460 hasConceptScore W2127705460C40767141 @default.
• W2127705460 hasConceptScore W2127705460C535046627 @default.
• W2127705460 hasConceptScore W2127705460C54602769 @default.
• W2127705460 hasConceptScore W2127705460C55493867 @default.
• W2127705460 hasConceptScore W2127705460C60987743 @default.
• W2127705460 hasConceptScore W2127705460C71924100 @default.
• W2127705460 hasConceptScore W2127705460C86803240 @default.

• next