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• W2127715515 abstract "Complex urban air mixtures that realistically mimic urban smog can be generated for investigating adverse health effects. “Smog chambers” have been used for over 30 yr to conduct experiments for developing and testing photochemical models that predict ambient ozone (O3) concentrations and aerosol chemistry. These chambers were used to generate photochemical and nonirradiated systems, which were interfaced with an in vitro exposure system to compare the inflammatory effects of complex air pollutant mixtures with and without sunlight-driven chemistry. These are preliminary experiments in a new project to study the health effects of particulate matter and associated gaseous copollutants. Briefly, two matched outdoor chambers capable of using real sunlight were utilized to generate two test atmospheres for simultaneous exposures to cultured lung cells. One chamber was used to produce a photochemically active system, which ran from sunrise to sunset, producing O3 and the associated secondary products. A few hours after sunset, NO was added to titrate and remove completely the O3, forming NO2. In the second chamber, an equal amount of NO2 and the same amount of the 55-component hydrocarbon mixture used to setup the photochemical system in the first side were injected. A549 cells, from an alveolar type II-like cell line grown on membranous support, were exposed to the photochemical mixture or the “original” NO2/hydrocarbon mixture for 5 h and analyzed for inflammatory response (IL-8 mRNA levels) 4 h postexposure. In addition, a variation of this experiment was conducted to compare the photochemical system producing O3 and NO2, with a simple mixture of only the O3 and NO2. Our data suggest that the photochemically altered mixtures that produced secondary products induced about two- to threefold more IL-8 mRNA than the mixture of NO2 and hydrocarbons or O3. These results indicate that secondary products generated through the photochemical reactions of NOx and hydrocarbons may significantly contribute to the inflammatory responses induced by exposure to urban smog. From previous experience with relevant experiments, we know that many of these gaseous organic products would contribute to the formation of significant secondary organic particle mass in the presence of seed particles (including road dust or combustion products). In the absence of such particles, these gaseous products remained mostly as gases. These experiments show that photochemically produced gaseous products do influence the toxic responses of the cells in the absence of particles." @default.
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• W2127715515 date "2004-01-01" @default.
• W2127715515 modified "2023-10-17" @default.
• W2127715515 title "Photochemical Products in Urban Mixtures Enhance Inflammatory Responses in Lung Cells" @default.
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• W2127715515 doi "https://doi.org/10.1080/08958370490443196" @default.
• W2127715515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15204799" @default.
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