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• W2127718726 abstract "Growing evidence supports the involvement of brain-derived neurotrophic factor (BDNF) in mood disorders and the mechanism of action of antidepressant drugs. However, the relationship between BDNF and serotonergic signalling is poorly understood. Heterozygous mutants BDNF +/- mice were utilized to investigate the influence of BDNF on the serotonin (5-HT) system and the activity of the serotonin transporter (SERT) in the hippocampus. The zero net flux method of quantitative microdialysis revealed that BDNF +/- heterozygous mice have increased basal extracellular 5-HT levels in the hippocampus and decreased 5-HT reuptake capacity. In keeping with these results, the selective serotonin reuptake inhibitor paroxetine failed to increase hippocampal extracellular 5-HT levels in BDNF +/- mice while it produced robust effects in wild-type littermates. Using in-vitro autoradiography and synaptosome techniques, we investigated the causes of attenuated 5-HT reuptake in BDNF +/- mice. A significant decrease in [3H]citalopram-binding-site density in the CA3 subregion of the ventral hippocampus and a significant reduction in [3H]5-HT uptake in hippocampal synaptosomes, revealed mainly a decrease in SERT function. However, 5-HT1A autoreceptors were not desensitized in BDNF +/- mice. These results provide evidence that constitutive reductions in BDNF modulate SERT function reuptake in the hippocampus." @default.
• W2127718726 created "2016-06-24" @default.
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• W2127718726 date "2007-06-11" @default.
• W2127718726 modified "2023-10-16" @default.
• W2127718726 title "Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype" @default.
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• W2127718726 doi "https://doi.org/10.1017/s1461145707007857" @default.
• W2127718726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17559709" @default.
• W2127718726 hasPublicationYear "2007" @default.
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