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• W2127737819 abstract "The presence of an untreated chronic total coronary occlusion (CTO) is associated with a higher risk of ventricular arrhythmias (VAs). This increased risk may be modulated by the presence of an existing scar.To evaluate whether scar size is associated with VA in patients with an implantable cardioverter-defibrillator (ICD) and a CTO.In this retrospective study we included patients with a CTO that received an ICD between 2005 and 2015. Scar size was estimated using the Selvester QRS score on a baseline 12‑lead ECG. The primary endpoint was any appropriate ICD therapy.Our study population comprised 148 CTO patients with a median scar size at baseline of 18% (IQR, 9–27%). Patients with a scar size ≥18% more often had a CTO located in the left anterior descending artery and a higher proportion of poor left ventricular function (<35%) and infarct-related CTO compared to patients with a smaller scar size (<18%). During a median follow-up of 35 months (interquartile range [IQR], 8–60 months), 42 patients (28%) received appropriate ICD therapy. The cumulative 5-year event rate was higher in the patients with a large scar in comparison to those with a smaller or no scar (36% versus 19%, P = 0.04). Multivariable Cox regression analysis demonstrated that large scar and diabetes mellitus were independent factors associated with appropriate ICD therapy.In ICD recipients with an untreated CTO, a larger scar is an independent factor associated with an increased risk of VA." @default.
• W2127737819 created "2016-06-24" @default.
• W2127737819 creator A5049352256 @default.
• W2127737819 creator A5083786245 @default.
• W2127737819 date "2009-01-01" @default.
• W2127737819 modified "2023-10-16" @default.
• W2127737819 title "The QRS complex—a biomarker that “images” the heart: QRS scores to quantify myocardial scar in the presence of normal and abnormal ventricular conduction" @default.
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• W2127737819 doi "https://doi.org/10.1016/j.jelectrocard.2008.07.011" @default.
• W2127737819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18790501" @default.
• W2127737819 hasPublicationYear "2009" @default.
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