Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127742405> ?p ?o ?g. }
- W2127742405 endingPage "27" @default.
- W2127742405 startingPage "116" @default.
- W2127742405 abstract "Embryonic development is initiated after the fertilizing sperm contacts the egg and triggers a process termed egg activation, resulting in calcium release, cortical granule exocytosis, recruitment of maternal mRNAs, and cell cycle resumption. Heterotrimeric guanine nucleotide-binding proteins (G proteins) may be involved in mouse egg activation since inhibition of G protein beta gamma subunits partially inhibits sperm-induced cell cycle resumption. In addition, specific events of egg activation can be initiated in the absence of sperm by acetylcholine stimulation of mouse eggs overexpressing the human m1 muscarinic receptor, a G protein-coupled receptor. In somatic cell, G proteins in the Gq family couple ligand stimulation of the m1 muscarinic receptor to activation of phospholipase C, resulting in the production of inositol 1,4,5-trisphosphate (IP3) and IP3-mediated release of intracellular calcium. Since IP3-mediated calcium release is involved in egg activation at fertilization, we have examined the role of Gq family G proteins in both sperm-independent (muscarinic receptor-mediated) and sperm-induced egg activation using a function-blocking antibody raised against the common C-terminal region of Gq and G11 proteins. We show that this antibody effectively inhibits Gq family G proteins in mouse eggs by demonstrating that the antibody inhibits egg activation in response to stimulation of the m1 muscarinic receptor. This same antibody, however, does not inhibit sperm-induced egg activation events. These results indicate that although activation of Gq family G proteins can result in egg activation in the mouse, it is unlikely that these proteins are used by the sperm to initiate egg activation at fertilization." @default.
- W2127742405 created "2016-06-24" @default.
- W2127742405 creator A5002886426 @default.
- W2127742405 creator A5003569866 @default.
- W2127742405 creator A5025662544 @default.
- W2127742405 creator A5063587977 @default.
- W2127742405 creator A5081630269 @default.
- W2127742405 date "1998-06-01" @default.
- W2127742405 modified "2023-10-17" @default.
- W2127742405 title "Evidence that Gq family G proteins do not function in mouse egg activation at fertilization." @default.
- W2127742405 cites W108431095 @default.
- W2127742405 cites W1482441851 @default.
- W2127742405 cites W1497597518 @default.
- W2127742405 cites W1516430041 @default.
- W2127742405 cites W1522007155 @default.
- W2127742405 cites W1522965874 @default.
- W2127742405 cites W1534683572 @default.
- W2127742405 cites W1552150952 @default.
- W2127742405 cites W1590145665 @default.
- W2127742405 cites W1592751942 @default.
- W2127742405 cites W1594700207 @default.
- W2127742405 cites W1600700021 @default.
- W2127742405 cites W1602995462 @default.
- W2127742405 cites W1801735381 @default.
- W2127742405 cites W1936792410 @default.
- W2127742405 cites W1964368869 @default.
- W2127742405 cites W1978745809 @default.
- W2127742405 cites W1983585149 @default.
- W2127742405 cites W1984779994 @default.
- W2127742405 cites W1990540386 @default.
- W2127742405 cites W1990602082 @default.
- W2127742405 cites W1992965538 @default.
- W2127742405 cites W1994090158 @default.
- W2127742405 cites W1995376834 @default.
- W2127742405 cites W1995496629 @default.
- W2127742405 cites W1997205949 @default.
- W2127742405 cites W2001402428 @default.
- W2127742405 cites W2003694280 @default.
- W2127742405 cites W2005037686 @default.
- W2127742405 cites W2008052643 @default.
- W2127742405 cites W2009421992 @default.
- W2127742405 cites W2012485812 @default.
- W2127742405 cites W2015176049 @default.
- W2127742405 cites W2018637201 @default.
- W2127742405 cites W2025425793 @default.
- W2127742405 cites W2029266821 @default.
- W2127742405 cites W2029362083 @default.
- W2127742405 cites W2029988485 @default.
- W2127742405 cites W2033620401 @default.
- W2127742405 cites W2034384463 @default.
- W2127742405 cites W2040437816 @default.
- W2127742405 cites W2040742434 @default.
- W2127742405 cites W2041447266 @default.
- W2127742405 cites W2043184569 @default.
- W2127742405 cites W2044804726 @default.
- W2127742405 cites W2046298157 @default.
- W2127742405 cites W2053617528 @default.
- W2127742405 cites W2058298045 @default.
- W2127742405 cites W2061027592 @default.
- W2127742405 cites W2064541275 @default.
- W2127742405 cites W2067220125 @default.
- W2127742405 cites W2068259058 @default.
- W2127742405 cites W2070288681 @default.
- W2127742405 cites W2078826636 @default.
- W2127742405 cites W2080258138 @default.
- W2127742405 cites W2080875376 @default.
- W2127742405 cites W2087654747 @default.
- W2127742405 cites W2095777195 @default.
- W2127742405 cites W2100837269 @default.
- W2127742405 cites W2101731958 @default.
- W2127742405 cites W2113393270 @default.
- W2127742405 cites W2132750026 @default.
- W2127742405 cites W2137901143 @default.
- W2127742405 cites W2143242953 @default.
- W2127742405 cites W2144634347 @default.
- W2127742405 cites W2150083639 @default.
- W2127742405 cites W2155495069 @default.
- W2127742405 cites W2183345293 @default.
- W2127742405 cites W2184717106 @default.
- W2127742405 cites W2326057957 @default.
- W2127742405 cites W23642858 @default.
- W2127742405 cites W2407549567 @default.
- W2127742405 cites W2416508542 @default.
- W2127742405 cites W2416574324 @default.
- W2127742405 cites W2444084001 @default.
- W2127742405 cites W50079648 @default.
- W2127742405 cites W592099852 @default.
- W2127742405 cites W654843005 @default.
- W2127742405 cites W2010040446 @default.
- W2127742405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9640335" @default.
- W2127742405 hasPublicationYear "1998" @default.
- W2127742405 type Work @default.
- W2127742405 sameAs 2127742405 @default.
- W2127742405 citedByCount "26" @default.
- W2127742405 countsByYear W21277424052012 @default.
- W2127742405 countsByYear W21277424052013 @default.
- W2127742405 countsByYear W21277424052015 @default.
- W2127742405 countsByYear W21277424052016 @default.