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• W2127747618 abstract "The VraS/VraR two-component system (VraSR) regulates transcriptional induction of penicillin-binding protein 2 (encoded by pbp2) by vancomycin in Staphylococcus aureus. We have now defined the vraSR operon and determined that its induction by beta-lactams as well as by vancomycin is autoregulated. Induction of the pbp2 and vraSR operons by beta-lactams and related compounds within 1 hour after exposure to the antimicrobials was dependent on vraS. However, when a disk diffusion assay that can detect induction of genes over an extended time period was used, induction of the pbp2 operon was mediated by some beta-lactams, including oxacillin; this induction was independent of vraS." @default.
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• W2127747618 date "2006-01-01" @default.
• W2127747618 modified "2023-10-01" @default.
• W2127747618 title "VraSR Two-Component Regulatory System and Its Role in Induction of <i>pbp2</i> and <i>vraSR</i> Expression by Cell Wall Antimicrobials in <i>Staphylococcus aureus</i>" @default.
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• W2127747618 doi "https://doi.org/10.1128/aac.50.1.336-343.2006" @default.
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