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• W2127760350 abstract "Abstract Background Concomitant infections may influence HIV progression by causing chronic activation leading to decline in T-cell function. In the Americas, visceral (AVL) and tegumentary leishmaniasis (ATL) have emerged as important opportunistic infections in HIV-AIDS patients and both of those diseases have been implicated as potentially important co-factors in disease progression. We investigated whether leishmaniasis increases lymphocyte activation in HIV-1 co-infected patients. This might contribute to impaired cellular immune function. Methods To address this issue we analyzed CD4 + T absolute counts and the proportion of CD8 + T cells expressing CD38 in Leishmania /HIV co-infected patients that recovered after anti-leishmanial therapy. Results We found that, despite clinical remission of leishmaniasis, AVL co-infected patients presented a more severe immunossupression as suggested by CD4 + T cell counts under 200 cells/mm 3 , differing from ATL/HIV-AIDS cases that tends to show higher lymphocytes levels (over 350 cells/mm 3 ). Furthermore, five out of nine, AVL/HIV-AIDS presented low CD4 + T cell counts in spite of low or undetectable viral load. Expression of CD38 on CD8 + T lymphocytes was significantly higher in AVL or ATL/HIV-AIDS cases compared to HIV/AIDS patients without leishmaniasis or healthy subjects. Conclusions Leishmania infection can increase the degree of immune system activation in individuals concomitantly infected with HIV. In addition, AVL/HIV-AIDS patients can present low CD4 + T cell counts and higher proportion of activated T lymphocytes even when HIV viral load is suppressed under HAART. This fact can cause a misinterpretation of these laboratorial markers in co-infected patients." @default.
• W2127760350 created "2016-06-24" @default.
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• W2127760350 date "2010-12-01" @default.
• W2127760350 modified "2023-10-09" @default.
• W2127760350 title "High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load" @default.
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• W2127760350 doi "https://doi.org/10.1186/1471-2334-10-358" @default.
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