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• W2127776124 endingPage "120104" @default.
• W2127776124 startingPage "120104" @default.
• W2127776124 abstract "The increase in centrosome size in mitosis was described over a century ago, and yet it is poorly understood how centrioles, which lie at the core of centrosomes, organize the pericentriolar material (PCM) in this process. Now, structured illumination microscopy reveals in Drosophila that, before clouds of PCM appear, its proteins are closely associated with interphase centrioles in two tube-like layers: an inner layer occupied by centriolar microtubules, Sas-4, Spd-2 and Polo kinase; and an outer layer comprising Pericentrin-like protein (Dplp), Asterless (Asl) and Plk4 kinase. Centrosomin (Cnn) and γ-tubulin associate with this outer tube in G2 cells and, upon mitotic entry, Polo activity is required to recruit them together with Spd-2 into PCM clouds. Cnn is required for Spd-2 to expand into the PCM during this maturation process but can itself contribute to PCM independently of Spd-2. By contrast, the centrioles of spermatocytes elongate from a pre-existing proximal unit during the G2 preceding meiosis. Sas-4 is restricted to the microtubule-associated, inner cylinder and Dplp and Cnn to the outer cylinder of this proximal part. γ-Tubulin and Asl associate with the outer cylinder and Spd-2 with the inner cylinder throughout the entire G2 centriole. Although they occupy different spatial compartments on the G2 centriole, Cnn, Spd-2 and γ-tubulin become diminished at the centriole upon entry into meiosis to become part of PCM clouds." @default.
• W2127776124 created "2016-06-24" @default.
• W2127776124 creator A5039099818 @default.
• W2127776124 creator A5088936355 @default.
• W2127776124 date "2012-08-01" @default.
• W2127776124 modified "2023-09-23" @default.
• W2127776124 title "Structured illumination of the interface between centriole and peri-centriolar material" @default.
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• W2127776124 doi "https://doi.org/10.1098/rsob.120104" @default.
• W2127776124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3438536" @default.
• W2127776124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22977736" @default.
• W2127776124 hasPublicationYear "2012" @default.
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