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• W2127776327 abstract "BackgroundDecreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pollution.ObjectiveWe determined in 4,326 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) whether four single-nucleotide polymorphisms in three genes [CCND1 (rs9344 [P242P], rs667515), p53 (rs1042522 [R72P]), and p21 (rs1801270 [S31R])] modified the previously observed attenuation of the decline in the forced expiratory flow between 25% and 75% of the forced vital capacity (FEF25–75) associated with improved air quality.MethodsSubjects of the prospective population-based SAPALDIA cohort were assessed in 1991 and 2002 by spirometry, questionnaires, and biological sample collection for genotyping. We assigned spatially resolved concentrations of particulate matter with aerodynamic diameter ≤ 10 μm (PM10) to each participant’s residential history 12 months before the baseline and follow-up assessments.ResultsThe effect of diminishing PM10 exposure on FEF25–75 decline appeared to be modified by p53 R72P, CCND1 P242P, and CCND1 rs667515. For example, a 10-μg/m3 decline in aver-age PM10 exposure over an 11-year period attenuated the average annual decline in FEF25–75 by 21.33 mL/year (95% confidence interval, 10.57–32.08) among participants homozygous for the CCND1 (P242P) GG genotype, by 13.72 mL/year (5.38–22.06) among GA genotypes, and by 6.00 mL/year (−4.54 to 16.54) among AA genotypes.ConclusionsOur results suggest that cell cycle control genes may modify the degree to which improved air quality may benefit respiratory function in adults." @default.
• W2127776327 created "2016-06-24" @default.
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• W2127776327 date "2009-09-01" @default.
• W2127776327 modified "2023-10-15" @default.
• W2127776327 title "Decreased PM ₁₀ Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in <i>p53</i> , <i>p21</i> , and <i>CCND1</i> Modify This Effect" @default.
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• W2127776327 cites W1973380621 @default.
• W2127776327 cites W1975754118 @default.
• W2127776327 cites W1979148740 @default.
• W2127776327 cites W1983252706 @default.
• W2127776327 cites W1983462139 @default.
• W2127776327 cites W1989652341 @default.
• W2127776327 cites W1993963294 @default.
• W2127776327 cites W2010467665 @default.
• W2127776327 cites W2014903037 @default.
• W2127776327 cites W2017141716 @default.
• W2127776327 cites W2022087304 @default.
• W2127776327 cites W2022722571 @default.
• W2127776327 cites W2026818750 @default.
• W2127776327 cites W2034540650 @default.
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• W2127776327 cites W2065753743 @default.
• W2127776327 cites W2070419199 @default.
• W2127776327 cites W2071133565 @default.
• W2127776327 cites W2074461433 @default.
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• W2127776327 doi "https://doi.org/10.1289/ehp.0800430" @default.
• W2127776327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2737020" @default.
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