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• W2127779890 abstract "Farnesyltransferase inhibitors (FTIs) usually cause growth inhibition, but in certain preclinical settings they have been shown to induce apoptosis, a clinically desirable response. In this study, we show that the proapoptotic effects of FTIs in Ras-transformed cells are masked by activation of phosphatidylinositol 3'-kinase (PI3'K) or AKT, which are controlled by cytokines and integrins. The results implied that FTIs disrupt a signal that is crucial for survival of malignant cells, but not normal cells, if the PI3'K-AKT pathway is inactivated. Our findings have implications for clinical applications of FTIs where apoptotic responses would be preferred." @default.
• W2127779890 created "2016-06-24" @default.
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• W2127779890 date "1999-09-01" @default.
• W2127779890 modified "2023-09-23" @default.
• W2127779890 title "Activation of the PI3'K-AKT pathway masks the proapoptotic effects of farnesyltransferase inhibitors." @default.
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• W2127779890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10485456" @default.
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