FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127780191> ?p ?o ?g. }

• W2127780191 endingPage "1120" @default.
• W2127780191 startingPage "1114" @default.
• W2127780191 abstract "In humans, proarrhythmia during therapy with action potential-prolonging drugs can be associated with hypokalemia often provoked by concomitant administration of diuretic agents. Consequently, therapy with class III antiarrhythmics and K(+)-sparing diuretics, such as triamterene, may be indicated. Triamterene, along with its K(+)-sparing properties, exhibits other pharmacological effects. In the heart, it can increase action potential duration (guinea pig atria and papillary muscles), protect against reperfusion-induced arrhythmias (rat), and increase the QT interval (humans). Therefore, studies were undertaken to assess effects of triamterene on cardiac K+ repolarizing currents. Guinea pig ventricular myocytes were superfused at 30 degrees C with Cd(2+)-containing solution to block Isi and held at -40 mV to inactivate INa. Currents were measured in the whole-cell configuration of the patch-clamp technique. The delayed rectifier outward current (IK) was elicited by short (250-millisecond) and long (5000-millisecond) depolarizing pulses, and time-independent currents were assessed by a rapid ramp test protocol. After high-voltage long pulses (+50 mV; 5000 milliseconds), tail current amplitude of the slow component of IK (IKs) was decreased 36 +/- 6% (n = 6) and 51 +/- 8% (n = 6) by triamterene 10(-5) and 10(-4) mol/L, respectively. After low-voltage short pulses (-20 mV; 250 milliseconds), tail current amplitude corresponding essentially to the rapid component of IK (IKr) was decreased only 14 +/- 11% (n = 9) and 19 +/- 10% (n = 10) by triamterene 10(-5) and 10(-4) mol/L, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2127780191 created "2016-06-24" @default.
• W2127780191 creator A5056193648 @default.
• W2127780191 creator A5080359453 @default.
• W2127780191 date "1994-06-01" @default.
• W2127780191 modified "2023-09-25" @default.
• W2127780191 title "Triamterene inhibits the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes." @default.
• W2127780191 cites W1518891115 @default.
• W2127780191 cites W1968652458 @default.
• W2127780191 cites W1975869151 @default.
• W2127780191 cites W1976036164 @default.
• W2127780191 cites W1976477465 @default.
• W2127780191 cites W1985780140 @default.
• W2127780191 cites W1995340775 @default.
• W2127780191 cites W1999559088 @default.
• W2127780191 cites W2016275322 @default.
• W2127780191 cites W2027867630 @default.
• W2127780191 cites W2028179937 @default.
• W2127780191 cites W2031160066 @default.
• W2127780191 cites W2051523620 @default.
• W2127780191 cites W2058311825 @default.
• W2127780191 cites W2059347766 @default.
• W2127780191 cites W2066138023 @default.
• W2127780191 cites W2071102501 @default.
• W2127780191 cites W2074929809 @default.
• W2127780191 cites W2079971596 @default.
• W2127780191 cites W2081310823 @default.
• W2127780191 cites W2092937587 @default.
• W2127780191 cites W2415150556 @default.
• W2127780191 doi "https://doi.org/10.1161/01.res.74.6.1114" @default.
• W2127780191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8187277" @default.
• W2127780191 hasPublicationYear "1994" @default.
• W2127780191 type Work @default.
• W2127780191 sameAs 2127780191 @default.
• W2127780191 citedByCount "19" @default.
• W2127780191 crossrefType "journal-article" @default.
• W2127780191 hasAuthorship W2127780191A5056193648 @default.
• W2127780191 hasAuthorship W2127780191A5080359453 @default.
• W2127780191 hasBestOaLocation W21277801911 @default.
• W2127780191 hasConcept C100837961 @default.
• W2127780191 hasConcept C118441451 @default.
• W2127780191 hasConcept C12554922 @default.
• W2127780191 hasConcept C126322002 @default.
• W2127780191 hasConcept C146403970 @default.
• W2127780191 hasConcept C147944092 @default.
• W2127780191 hasConcept C155730078 @default.
• W2127780191 hasConcept C170493617 @default.
• W2127780191 hasConcept C185263204 @default.
• W2127780191 hasConcept C185592680 @default.
• W2127780191 hasConcept C2777008848 @default.
• W2127780191 hasConcept C2777622974 @default.
• W2127780191 hasConcept C2778242168 @default.
• W2127780191 hasConcept C2778815084 @default.
• W2127780191 hasConcept C2780361556 @default.
• W2127780191 hasConcept C4141045 @default.
• W2127780191 hasConcept C50254741 @default.
• W2127780191 hasConcept C71924100 @default.
• W2127780191 hasConcept C84393581 @default.
• W2127780191 hasConcept C86803240 @default.
• W2127780191 hasConcept C94924445 @default.
• W2127780191 hasConcept C98274493 @default.
• W2127780191 hasConceptScore W2127780191C100837961 @default.
• W2127780191 hasConceptScore W2127780191C118441451 @default.
• W2127780191 hasConceptScore W2127780191C12554922 @default.
• W2127780191 hasConceptScore W2127780191C126322002 @default.
• W2127780191 hasConceptScore W2127780191C146403970 @default.
• W2127780191 hasConceptScore W2127780191C147944092 @default.
• W2127780191 hasConceptScore W2127780191C155730078 @default.
• W2127780191 hasConceptScore W2127780191C170493617 @default.
• W2127780191 hasConceptScore W2127780191C185263204 @default.
• W2127780191 hasConceptScore W2127780191C185592680 @default.
• W2127780191 hasConceptScore W2127780191C2777008848 @default.
• W2127780191 hasConceptScore W2127780191C2777622974 @default.
• W2127780191 hasConceptScore W2127780191C2778242168 @default.
• W2127780191 hasConceptScore W2127780191C2778815084 @default.
• W2127780191 hasConceptScore W2127780191C2780361556 @default.
• W2127780191 hasConceptScore W2127780191C4141045 @default.
• W2127780191 hasConceptScore W2127780191C50254741 @default.
• W2127780191 hasConceptScore W2127780191C71924100 @default.
• W2127780191 hasConceptScore W2127780191C84393581 @default.
• W2127780191 hasConceptScore W2127780191C86803240 @default.
• W2127780191 hasConceptScore W2127780191C94924445 @default.
• W2127780191 hasConceptScore W2127780191C98274493 @default.
• W2127780191 hasIssue "6" @default.
• W2127780191 hasLocation W21277801911 @default.
• W2127780191 hasLocation W21277801912 @default.
• W2127780191 hasOpenAccess W2127780191 @default.
• W2127780191 hasPrimaryLocation W21277801911 @default.
• W2127780191 hasRelatedWork W1965717915 @default.
• W2127780191 hasRelatedWork W1977151728 @default.
• W2127780191 hasRelatedWork W1990349940 @default.
• W2127780191 hasRelatedWork W2041168023 @default.
• W2127780191 hasRelatedWork W2048011947 @default.
• W2127780191 hasRelatedWork W2063274861 @default.
• W2127780191 hasRelatedWork W2127780191 @default.
• W2127780191 hasRelatedWork W2171646634 @default.
• W2127780191 hasRelatedWork W2408030367 @default.
• W2127780191 hasRelatedWork W3142064477 @default.

• next