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• W2127788241 abstract "Purpose To evaluate the quality of 24-hour intraocular pressure (IOP) control between morning- and evening-dosed travoprost in primary open-angle glaucoma patients. Design Prospective, crossover, double-masked comparison. Methods After a 6-week medicine-free period, 33 patients were randomized to receive travoprost dosed in the morning or evening. After 8 weeks of treatment, a 24-hour IOP curve was performed at 6 am, 10 am, 2 pm, 6 pm, 10 pm, and 2 am. Patients were then treated with the opposite dosing regimen for another 8 weeks, after which the 24-hour IOP curve was repeated. Main Outcome Measures Twenty-four–hour IOP. Results The untreated mean 24-hour IOP was 23.6±2.0 mmHg. There were no differences for mean 24-hour IOP between the morning (17.5±1.9 mmHg) and evening (17.3±1.9 mmHg) dosings (P = 0.7). At 10 am, the evening dosing provided a statistically lower IOP (17.2±2.1 mmHg) than the morning dosing (19.1±2.5 mmHg) (P = 0.02). Evening dosing demonstrated a statistically lower 24-hour fluctuation of IOP (3.2±1.0 mmHg) than morning dosing (4.0±1.5 mmHg) (P = 0.01). Safety was similar, with conjunctival hyperemia being the most common adverse event (n = 9 [27% for morning dosing] and n = 11 [33% for evening dosing], P = 0.6). Conclusions This study suggests that both morning and evening dosings of travoprost provide effective 24-hour IOP reduction. However, the evening dosing of travoprost demonstrates slightly greater daytime efficacy, with a narrower range of 24-hour pressure. To evaluate the quality of 24-hour intraocular pressure (IOP) control between morning- and evening-dosed travoprost in primary open-angle glaucoma patients. Prospective, crossover, double-masked comparison. After a 6-week medicine-free period, 33 patients were randomized to receive travoprost dosed in the morning or evening. After 8 weeks of treatment, a 24-hour IOP curve was performed at 6 am, 10 am, 2 pm, 6 pm, 10 pm, and 2 am. Patients were then treated with the opposite dosing regimen for another 8 weeks, after which the 24-hour IOP curve was repeated. Twenty-four–hour IOP. The untreated mean 24-hour IOP was 23.6±2.0 mmHg. There were no differences for mean 24-hour IOP between the morning (17.5±1.9 mmHg) and evening (17.3±1.9 mmHg) dosings (P = 0.7). At 10 am, the evening dosing provided a statistically lower IOP (17.2±2.1 mmHg) than the morning dosing (19.1±2.5 mmHg) (P = 0.02). Evening dosing demonstrated a statistically lower 24-hour fluctuation of IOP (3.2±1.0 mmHg) than morning dosing (4.0±1.5 mmHg) (P = 0.01). Safety was similar, with conjunctival hyperemia being the most common adverse event (n = 9 [27% for morning dosing] and n = 11 [33% for evening dosing], P = 0.6). This study suggests that both morning and evening dosings of travoprost provide effective 24-hour IOP reduction. However, the evening dosing of travoprost demonstrates slightly greater daytime efficacy, with a narrower range of 24-hour pressure." @default.
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• W2127788241 date "2006-03-01" @default.
• W2127788241 modified "2023-10-16" @default.
• W2127788241 title "24-Hour Intraocular Pressure Control Obtained with Evening- versus Morning-Dosed Travoprost in Primary Open-Angle Glaucoma" @default.
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• W2127788241 doi "https://doi.org/10.1016/j.ophtha.2005.10.053" @default.
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