FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127788339> ?p ?o ?g. }

• W2127788339 endingPage "467" @default.
• W2127788339 startingPage "447" @default.
• W2127788339 abstract "Summary The plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria utilizes a type III secretion (T3S) system to inject effector proteins into eukaryotic cells. T3S substrate specificity is controlled by HpaC, which promotes secretion of translocon and effector proteins but prevents efficient secretion of the early substrate HrpB2. HpaC and HrpB2 interact with the C‐terminal domain (HrcU C ) of the FlhB/YscU homologue HrcU. Here, we provide experimental evidence that HrcU is proteolytically cleaved at the conserved NPTH motif, which is required for binding of both HpaC and HrpB2 to HrcU C . The results of mutant studies showed that cleavage of HrcU contributes to pathogenicity and secretion of late substrates but is dispensable for secretion of HrpB2, which is presumably secreted prior to HrcU cleavage. The introduction of a point mutation (Y318D) into HrcU C activated secretion of late substrates in the absence of HpaC and suppressed the hpaC mutant phenotype. However, secretion of HrpB2 was unaffected by HrcU Y318D , suggesting that the export of early and late substrates is controlled by independent mechanisms that can be uncoupled. As HrcU Y318D did not interact with HrpB2 and HpaC, we propose that the substrate specificity switch leads to the release of HrcU C ‐bound HrpB2 and HpaC." @default.
• W2127788339 created "2016-06-24" @default.
• W2127788339 creator A5050164204 @default.
• W2127788339 creator A5055624829 @default.
• W2127788339 date "2010-11-24" @default.
• W2127788339 modified "2023-10-16" @default.
• W2127788339 title "Secretion of early and late substrates of the type III secretion system from Xanthomonas is controlled by HpaC and the C-terminal domain of HrcU" @default.
• W2127788339 cites W1513333509 @default.
• W2127788339 cites W1555021163 @default.
• W2127788339 cites W1567074356 @default.
• W2127788339 cites W1691665820 @default.
• W2127788339 cites W1824058431 @default.
• W2127788339 cites W1826109265 @default.
• W2127788339 cites W1899522406 @default.
• W2127788339 cites W1966881422 @default.
• W2127788339 cites W1967563710 @default.
• W2127788339 cites W1972431062 @default.
• W2127788339 cites W1974434374 @default.
• W2127788339 cites W1974631785 @default.
• W2127788339 cites W1978399016 @default.
• W2127788339 cites W1978473203 @default.
• W2127788339 cites W1980577924 @default.
• W2127788339 cites W1984295003 @default.
• W2127788339 cites W1986710302 @default.
• W2127788339 cites W1991831438 @default.
• W2127788339 cites W1992705790 @default.
• W2127788339 cites W1994729386 @default.
• W2127788339 cites W1997628323 @default.
• W2127788339 cites W2002840796 @default.
• W2127788339 cites W2002875716 @default.
• W2127788339 cites W2003246915 @default.
• W2127788339 cites W2007679081 @default.
• W2127788339 cites W2016574337 @default.
• W2127788339 cites W2016667239 @default.
• W2127788339 cites W2017409838 @default.
• W2127788339 cites W2019978236 @default.
• W2127788339 cites W2026418105 @default.
• W2127788339 cites W2027181869 @default.
• W2127788339 cites W2029857406 @default.
• W2127788339 cites W2034394264 @default.
• W2127788339 cites W2035657547 @default.
• W2127788339 cites W2038131958 @default.
• W2127788339 cites W2042447268 @default.
• W2127788339 cites W2043713273 @default.
• W2127788339 cites W2046359764 @default.
• W2127788339 cites W2047809120 @default.
• W2127788339 cites W2051359148 @default.
• W2127788339 cites W2051374647 @default.
• W2127788339 cites W2059697697 @default.
• W2127788339 cites W2060005457 @default.
• W2127788339 cites W2062688070 @default.
• W2127788339 cites W2065103401 @default.
• W2127788339 cites W2066314288 @default.
• W2127788339 cites W2066834921 @default.
• W2127788339 cites W2067925966 @default.
• W2127788339 cites W2068532894 @default.
• W2127788339 cites W2084852164 @default.
• W2127788339 cites W2089040112 @default.
• W2127788339 cites W2091595468 @default.
• W2127788339 cites W2091877974 @default.
• W2127788339 cites W2092245702 @default.
• W2127788339 cites W2095856124 @default.
• W2127788339 cites W2098724843 @default.
• W2127788339 cites W2104875904 @default.
• W2127788339 cites W2108285818 @default.
• W2127788339 cites W2109187683 @default.
• W2127788339 cites W2110553890 @default.
• W2127788339 cites W2111595188 @default.
• W2127788339 cites W2112596893 @default.
• W2127788339 cites W2115447566 @default.
• W2127788339 cites W2117865915 @default.
• W2127788339 cites W2122549684 @default.
• W2127788339 cites W2130723259 @default.
• W2127788339 cites W2141037335 @default.
• W2127788339 cites W2141219835 @default.
• W2127788339 cites W2144251138 @default.
• W2127788339 cites W2155868153 @default.
• W2127788339 cites W2157735947 @default.
• W2127788339 cites W2157774104 @default.
• W2127788339 cites W2158741380 @default.
• W2127788339 cites W2158937196 @default.
• W2127788339 cites W2161767156 @default.
• W2127788339 cites W2162515800 @default.
• W2127788339 cites W2163670463 @default.
• W2127788339 cites W2164905805 @default.
• W2127788339 cites W2319938745 @default.
• W2127788339 cites W2331589689 @default.
• W2127788339 cites W2334242896 @default.
• W2127788339 cites W56081268 @default.
• W2127788339 doi "https://doi.org/10.1111/j.1365-2958.2010.07461.x" @default.
• W2127788339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3040844" @default.
• W2127788339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21219463" @default.
• W2127788339 hasPublicationYear "2010" @default.
• W2127788339 type Work @default.
• W2127788339 sameAs 2127788339 @default.
• W2127788339 citedByCount "25" @default.
• W2127788339 countsByYear W21277883392012 @default.
• W2127788339 countsByYear W21277883392013 @default.

• next