FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127788608> ?p ?o ?g. }

• W2127788608 endingPage "1797" @default.
• W2127788608 startingPage "1791" @default.
• W2127788608 abstract "Demographic and family studies support the existence of a genetic contribution to the pathogenesis of IgA nephropathy, but results from genetic association studies of candidate genes are inconsistent. To systematically survey common genetic variation in this disease, we performed a genome-wide analysis in a cohort of patients with IgA nephropathy selected from the UK Glomerulonephritis DNA Bank. We used two groups of controls: parents of affected individuals and previously genotyped, unaffected, ancestry-matched individuals from the 1958 British Birth Cohort and the UK Blood Service. We genotyped 914 affected or family controls for 318,127 single nucleotide polymorphisms (SNPs). Filtering for low genotype call rates and inferred non-European ancestry left 533 genotyped individuals (187 affected children) for the family-based association analysis and 244 cases and 4980 controls for the case-control analysis. A total of 286,200 SNPs with call rates >95% were available for analysis. Genome-wide analysis showed a strong signal of association on chromosome 6p in the region of the MHC (P = 1 × 10(-9)). The two most strongly associated SNPs showed consistent association in both family-based and case-control analyses. HLA imputation analysis showed that the strongest association signal arose from a combination of DQ loci with some support for an independent HLA-B signal. These results suggest that the HLA region contains the strongest common susceptibility alleles that predispose to IgA nephropathy in the European population." @default.
• W2127788608 created "2016-06-24" @default.
• W2127788608 creator A5010751837 @default.
• W2127788608 creator A5013821870 @default.
• W2127788608 creator A5016286778 @default.
• W2127788608 creator A5025138242 @default.
• W2127788608 creator A5033795948 @default.
• W2127788608 creator A5036848232 @default.
• W2127788608 creator A5041270389 @default.
• W2127788608 creator A5045782628 @default.
• W2127788608 creator A5052464841 @default.
• W2127788608 creator A5061037871 @default.
• W2127788608 creator A5063320031 @default.
• W2127788608 creator A5064727417 @default.
• W2127788608 creator A5065730986 @default.
• W2127788608 creator A5083628704 @default.
• W2127788608 creator A5090465511 @default.
• W2127788608 creator A5091771874 @default.
• W2127788608 date "2010-10-01" @default.
• W2127788608 modified "2023-10-06" @default.
• W2127788608 title "HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis" @default.
• W2127788608 cites W1500261682 @default.
• W2127788608 cites W1601905530 @default.
• W2127788608 cites W1849481770 @default.
• W2127788608 cites W1975295697 @default.
• W2127788608 cites W1981223276 @default.
• W2127788608 cites W1999803356 @default.
• W2127788608 cites W2008599922 @default.
• W2127788608 cites W2011555335 @default.
• W2127788608 cites W2018823764 @default.
• W2127788608 cites W2022275373 @default.
• W2127788608 cites W2033222718 @default.
• W2127788608 cites W2052342854 @default.
• W2127788608 cites W2056866499 @default.
• W2127788608 cites W2059251603 @default.
• W2127788608 cites W2059542829 @default.
• W2127788608 cites W2059543915 @default.
• W2127788608 cites W2060913290 @default.
• W2127788608 cites W2061396672 @default.
• W2127788608 cites W2072375720 @default.
• W2127788608 cites W2075701003 @default.
• W2127788608 cites W2077599914 @default.
• W2127788608 cites W2080167581 @default.
• W2127788608 cites W2081056319 @default.
• W2127788608 cites W2082593263 @default.
• W2127788608 cites W2084732457 @default.
• W2127788608 cites W2096117226 @default.
• W2127788608 cites W2100469323 @default.
• W2127788608 cites W2108169091 @default.
• W2127788608 cites W2115939568 @default.
• W2127788608 cites W2119004823 @default.
• W2127788608 cites W2138345444 @default.
• W2127788608 cites W2148825606 @default.
• W2127788608 cites W2150910069 @default.
• W2127788608 cites W2166833206 @default.
• W2127788608 cites W2330813625 @default.
• W2127788608 cites W2615005980 @default.
• W2127788608 cites W4239867451 @default.
• W2127788608 doi "https://doi.org/10.1681/asn.2010010076" @default.
• W2127788608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3013538" @default.
• W2127788608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20595679" @default.
• W2127788608 hasPublicationYear "2010" @default.
• W2127788608 type Work @default.
• W2127788608 sameAs 2127788608 @default.
• W2127788608 citedByCount "224" @default.
• W2127788608 countsByYear W21277886082012 @default.
• W2127788608 countsByYear W21277886082013 @default.
• W2127788608 countsByYear W21277886082014 @default.
• W2127788608 countsByYear W21277886082015 @default.
• W2127788608 countsByYear W21277886082016 @default.
• W2127788608 countsByYear W21277886082017 @default.
• W2127788608 countsByYear W21277886082018 @default.
• W2127788608 countsByYear W21277886082019 @default.
• W2127788608 countsByYear W21277886082020 @default.
• W2127788608 countsByYear W21277886082021 @default.
• W2127788608 countsByYear W21277886082022 @default.
• W2127788608 countsByYear W21277886082023 @default.
• W2127788608 crossrefType "journal-article" @default.
• W2127788608 hasAuthorship W2127788608A5010751837 @default.
• W2127788608 hasAuthorship W2127788608A5013821870 @default.
• W2127788608 hasAuthorship W2127788608A5016286778 @default.
• W2127788608 hasAuthorship W2127788608A5025138242 @default.
• W2127788608 hasAuthorship W2127788608A5033795948 @default.
• W2127788608 hasAuthorship W2127788608A5036848232 @default.
• W2127788608 hasAuthorship W2127788608A5041270389 @default.
• W2127788608 hasAuthorship W2127788608A5045782628 @default.
• W2127788608 hasAuthorship W2127788608A5052464841 @default.
• W2127788608 hasAuthorship W2127788608A5061037871 @default.
• W2127788608 hasAuthorship W2127788608A5063320031 @default.
• W2127788608 hasAuthorship W2127788608A5064727417 @default.
• W2127788608 hasAuthorship W2127788608A5065730986 @default.
• W2127788608 hasAuthorship W2127788608A5083628704 @default.
• W2127788608 hasAuthorship W2127788608A5090465511 @default.
• W2127788608 hasAuthorship W2127788608A5091771874 @default.
• W2127788608 hasBestOaLocation W21277886081 @default.
• W2127788608 hasConcept C104317684 @default.
• W2127788608 hasConcept C106208931 @default.
• W2127788608 hasConcept C119857082 @default.

• next